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Bullboard - Stock Discussion Forum
Theratechnologies Inc
T.TH
Alternate Symbol(s):
THTX
Healthcare
Biotechnology
Theratechnologies Inc. is a Canada-based clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies addressing unmet medical needs. It markets prescription products for people with human immunodeficiency viruses (HIV) in the United States. The Company's research pipeline focuses on specialized therapies addressing unmet medical needs...
in HIV, nonalcoholic steatohepatitis (NASH) and oncology. Its medicines include Trogarzo and EGRIFTA SV (tesamorelin for injection). Trogarzo (ibalizumab-uiyk) injection is a long-acting monoclonal antibody which binds to domain 2 of the CD4 T cell receptors. EGRIFTA SV (tesamorelin for injection) is approved in the United States for the reduction of excess abdominal fat in people with HIV who have lipodystrophy. Its portfolio includes Phase I clinical trial of sudocetaxel zendusortide (TH1902), a novel peptide-drug conjugate (PDC), in patients with advanced ovarian cancer.
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TSX:TH - Post Discussion
Theratechnologies Inc
> Astra Zeneca ADC
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(200)
•••
palinc2000
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Post by
palinc2000
on Dec 09, 2022 11:17am
Astra Zeneca ADC
https://seekingalpha.com/pr/19050203-datopotamab-deruxtecan-showed-encouraging-and-durable-efficacy-in-patients-heavily-pretreated
(34)
•••
Wino115
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Comment by
Wino115
on Dec 09, 2022 1:54pm
Thanks Palinc -very interesting from the top dog. Astra is a great comp and leader now with Enhertu. This is sort of interesting to parse and compared to what (little) we know on TH1902. Here’s what Astra is showing for this breast cancer trial. Decent numbers, what you want to see to go to next step and commercialize. The hurdle isn’t massive and they had some safety issues, one person of the 41
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(78)
•••
jfm1330
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Comment by
jfm1330
on Dec 09, 2022 2:39pm
I looked at it, docetaxel is not the cytotoxic agent in any of the approved ADCs. Also, linker chemistry in ADCs is much more sophisticated than the simple dimethyl glutaryl linker TH1902 is using. I stand my ground, TH19P01 may be a valid ligand to sortilin and a valid carrier for a cytotoxic payload, but I highly doubt the dimethyl glutaryl linker they are using in TH1902 and docetaxel as a
...more
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