Theratechnologies Inc T.TH

2nd ADC toxicity summit

[scarlet1967]

https://storage.pardot.com/448062/1713868707LeQ1wadz/HW240322_46355_2nd_ADC_Toxicity_Summit_brochure_v8.pdf

"Targeting Sortilin (SORT1) to Unlock the Potential of Peptide Drug Conjugates (PDCs) in Oncology: Rapid Internalization within Minutes w

Unique Multimodal MOA & Safety Profile

• Understand the rationale for targeting the SORT1 receptor in cancer
• Discuss the unique toxicity profile of sudocetaxel zendusortide (TH1902), the lead PL from Theratechnologies' SORT1+ Technology ™ platform, that differs substantially fro the safety profile of taxanes, due to the multimodal MOA of the conjugate and the low levels of free circulating docetaxel
• Discuss how this multifaceted MOA with improved safety profile can lead to prolonge regression of disease and enable combinations with ADCs, PDCs and other anti-can therapies
• Discuss the ongoing phase I clinical development of sudocetaxel zendusortide, focus on dose optimization"

So Christian is speaking at this summit this time the focus is toxicity/ safety profile of the drug!

Have they had more human data so far as the issue with the drug and abrupt stop of the clinical trial initially was because of toxicity/safety concerns??

[Trogarzon]

Still discussing... and we are open for discussing partnership and are in a strong negociation position... lol

[Trogarzon]

They dilevered a 50M discussion about safety after 3 years.... bravo to all the team.  There come a time when apart from advancement of knowledge there is a fondamental question, what's in it for me the shareholder.  Well I know the answer and so most of you, we have until May to vote our conscience whatever the way they organised the elections last october.

[Lee430]

Scarlet1967, I noticed Thera’s time slot (10AM on day one) and it appears to be a decent one, is that correct?

[Mannequin]

correct 10am  

[Lee430]

I didn't word that correctly, what I was trying to find out is if that 10:00 a.m. slot is a good slot as it seems their other presentations weren't exactly prime time.

[Trogarzon]

It's in July.. we're in May... the 9th is next week....

[scarlet1967]

      The time is ok, this summit seems to be exploring multiple aspects of toxicity both in vivo and in clinical settings. Christian's presentation seems to be focused on the in vivo part however he is going to elaborate about the dose optimization in the part3 of phase1. The question is since the first patient was dosed on the higher level on or before March