Ceapro Inc V.CZO

Second Mysterious Formulation of Avenanthramide:

[prophetoffactz]

Others have tested avenanthramide before and it is in oat bran, etc. What makes CZO's special? CZO is the only one in the world that can produce natural avenanthramide at scale globally. CZO is positioned to take avantage of the significant body of preclinical research on avenanthramide for various diseases as can be seen at PubMed, for example.

I need clarification, but CZO may have also selected only the most essential part of avenanthramide responsible for it being a bioactive. It has created a highly purified, standardized pharma-grade pill. This is a first in history, I believe. Does the CZO advantage stop there? CZO has refered to a second mysterious formulation that it is also developing for the coming trial. 

"In planning for an extension into a Phase 2a (subject to Phase 1 outcomes), Ceapro’s R&D group manufactured sufficient additional GMP batches of avenanthramides active ingredient powder for a second formulation of avenanthramides pills." News release

As a delivery technology company has CZO impregnated its unique and highly purifed, pharma-grade powder of avenanthramide into one of its newer proprietary PGX delivery carriers? We've seen how CZO's carriers can tranform CoQ10 bioavailability data. PGX can also transform YBG. After understanding how CZO's avenanthramide pill works alone in humans and the optimal dose, does the second mysterious formulation seek to further enhance results with a PGX carrier?

Great Promise:

"The safety and bioavailability study will evaluate avenanthramides as a stand-alone therapy or potentially in combination with carriers recently developed using our PGX technology to address some inflammation-based diseases, which we believe shows great promise.”" News release

Do we have PGX-YBG-Alginate/CoQ10 with a blowout formulation of avenanthramide that we've never seen before? PGX-YBG is also an anti-inflammatory. It is a Trojan Horse that can hijack macrophages? Slow, extended release? Highly bioavailable? Delivers deeply into heart tissue?
 
Gilles has mentioned that the non-steroidal anti-inflammatory market is worth $60 billion per year. 

Avenanthramide was the reason Gilles joined CZO. Here comes the trial with some mystery. A recent news release also said:

“The commencement of this study represents a noteworthy milestone in the development of our avenanthramide program and could be the most significant transformational step we have taken to date in executing on our strategy to expand Ceapro’s business model towards becoming a biopharmaceutical company with the potential to provide an innovative product into very large markets." News release

"Potential indications for the systemic use of Ceapro’s avenanthramide are anticipated in the inflammatory component of vascular disease, atherosclerosis, diabetes, exercise induced inflammation, lung inflammation and, conceivably, in cardiovascular pathology associated with COVID-19." News release

[prophetoffactz]

What is your take, fossi? Is there a second PGX version of the avenanthramide pill producing a blowout response the likes of which the world has never seen before for avenanthramide using a newer PGX carrier? Gilles has explicitly mentioned the non-steroidal anti-inflammatory market is worth $60 billion, per year. There could be lots at stake given CZO's pipeline isn'tpriced into the stock

[fossi_2002]

Thanks Proph...for asking me about this. Since I am neither a biochemist nor a researcher, I can't answer that question for you. I am glad that you always keep us here on the board at a level with your publications, which enables us to understand Ceapro's research. But as I've shared before, I'm not sure we have a researcher or research department in-house at Ceapro itself that

[prophetoffactz]

"But as I've shared before, I'm not sure we have a researcher or research department in-house at Ceapro itself that can answer your questions." CZO has an in-house R&D team. It's also working with the Montreal Heart Institute which is well respected globally. Dr. Tardif is a leader globally in inflammation and heart disease having run important studies with colchicine.

[Everestbaker]

I can forgive GG for the trials but not developing a competent management team speaks volumes. He's being paid handsomely along with the stock options all these years yet has only hired a CRO this past year after much pressure from us shareholders.  As for proph, thanks for sharing your research findings - if only you worked for CZO (or maybe you already do). It just shows how much we

[prophetoffactz]

"why waste all those time and resources on a poorly executed BG pill study that we later find out a powder could be more efficient? Yes, pill has significant advantages with the form factor but it's ineffective, doesn't matter if it's a pill or not eh?" I'm glad that you know the results of clinical trials before they are completed. What are your stock tips given your

[boazklinghorn]

The problem is there was no ownership of the failure. There was no post study debrief and thus there was no learning. Gilles literally called it a bump in the road and spent zero time communicatiing what went wrong who was to blame and how things could be done better. As usual he took his paycheck and left the shareholders wondering what the hell just happened . Now we are heading down that road

[prophetoffactz]

"The problem is there was no ownership of the failure. There was no post study debrief and thus there was no learning. Gilles literally called it a bump in the road and spent zero time communicatiing what went wrong who was to blame and how things could be done better." He said the pill trial was a failure and moved on. He talked about certain data. It was a bump in the road. The

[boazklinghorn]

 "The trial didn't work. That's part of science." Calling BS on that, even I know thats nonsense. If you fail and you dont know why you failed you will fail again in the same way. All we know is that Gilles wanted a pill appartently without any consideration as to how this formulation would dislove in the gut.. He just wanted a pill full stop. This is not science this is