Ceapro Inc V.CZO

AEZS's diagnostic test:

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Macimorelin is the first and only US Food and Drug Administration (FDA)-approved oral drug indicated for the diagnosis of adult GH deficiency (AGHD), a rare endocrine disorder. In clinical trials, macimorelin demonstrated comparable diagnostic accuracy to the gold standard GH stimulation test, the insulin tolerance test (ITT) [4]. Potential advantages of macimorelin over the ITT include better tolerability and greater convenience. Macimorelin has no absolute contraindications [1], unlike the ITT, which is contraindicated in elderly populations and in patients with cardiovascular disease or seizure disorders [2,[5], [6], [7]].Safety, tolerability, pharmacokinetics, and pharmacodynamics of macimorelin in healthy adults: Results of a single-dose, randomized controlled study - ScienceDirect

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Bing: Aeterna Zentaris has developed a growth hormone deficiency (GHD) test using macimorelin, which offers several advantages compared to traditional GH-stimulation tests: Simplicity: The macimorelin test is straightforward and easy to administer. It involves oral administration of macimorelin to the child, followed by blood sample collection

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GHRYVELIN gave a similar number of negative test results for growth hormone deficiency as a comparator test; however, it gives fewer positive test results than the comparator. EMA considered that it is a priority to avoid over-diagnosis of adult growth hormone deficiency and that GHRYVELIN helps confirm positive diagnosis and so avoid unnecessary treatment of patients with a false