Medicure Inc V.MPH

According to case reports, treatment with PLP can prevent

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 2) May Be Better for Some Forms of Vitamin B6-Dependent Seizures The lack of vitamin B6 can cause severe neurological damage right after birth; it usually results in seizures, known as vitamin B6-dependent epilepsy. Intravenous pyridoxine is the treatment of choice and can be lifesaving [56, 57, 58]. A rare subtype of this disorder is so-called PLP-dependent epilepsy. It occurs due to mutations in the pyridoxine-5’-phosphate oxidase (PNPO). These patients require large doses of PLP as the liver can’t produce it from pyridoxine [64, 65]. According to multiple case reports, prompt treatment with PLP can prevent permanent brain damage and death [66, 65, 67]. Some authors have successfully treated other types of seizures with vitamin B6, and they have reported better results with PLP compared with pyridoxine [58, 68]. We can’t make conclusions based on these case reports. Further studies should evaluate the safety and efficacy of PLP for vitamin B6-dependent seizures.

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if we get FDA approval we also recieve a fast track voucher worth 100 - 200 million dollars.  The lack of vitamin B6 can cause severe neurological damage right after birth; it usually results in seizures, known as vitamin B6-dependent epilepsy. Intravenous pyridoxine is the treatment of choice and can be lifesaving [56, 57, 58]. A rare subtype of this disorder is so-called PLP-dependent