Theralase Technologies Inc. V.TLT

Listened to 2 PDT talks

[enriquesuave]

Lilge and Sarah Chamberland.  Very good presentations. The animal studies are still ongoing. In vitro they had 100% Tumor cell kill.  Animal studies looking good it seems, but still ongoing.   Dr Lilge was on ways to achieve proper dosage for Lung cancer   Pretty detailed stuff.

[CAinPlap]

Thanks enriquesuave for a post that relates to TLT. Was beginning to think this was a political forum. Don't you guys have facebook accounts you can spew your political BS and hate for each other on?

[Hankerchief]

.....and Chamberland is using TLD 1433?  TIA

[enriquesuave]

Yes they are using TLD-1433.  She is from Roswell.  She said they were using Dr Lilge's Full monte software as well. and was very positive about it.  There must be collaborations behind the scenes IMO.  One day we shall find out about it.

[Eoganacht]

Yes, she called it Dr. Lilge's wonderful software.

[Jaro1977]

Yes, she mentioned TLD-1433 in her presentation.  I asked why they decided to use TLD1433 but they moved on to the next presentation.  I also listened in

[enriquesuave]

I asked her directly on the chat if the results seen were better than Photofrin.  She said the trials were still ongoing so did not respond directly, but said that results with Photofrin were very good, but that using TLD-1433 provided a way to instill the Photosensitisor rather than IV.  My guess is that if results are same or better, then they would rather instil than IV so as to avoid

[fredgoodwinson]

Much obliged Enrique.   Dr.Lilge was scheduled to speak at 1530hrs local on ‘PDT dosimetry approaches for peripheral Lung Cancer. Preclinical studies’ followed immediately by Sarah Chamberlain with ‘Pretreatment Plan Development for Intraoperative Photodynamic Therapy at 1545hrs.   Dr.Lilge was then scheduled to speak again on Interstitial PDT.   Roswell Park have a

[enriquesuave]

Hi Fred, I listened to most of it while I was working out.  So it I can recall he mainly addressed activation with light.  Spoke about a fairly routine procedure now where they would infuse the lungs with a Stean solution while in vivo which would greatly enhance the PDT effect and Dosimetry..  The model he spoke of was with ALA.  

[fredgoodwinson]

Thanks enrique - dont think that we`ve seen anything yet. This Tech is close to the Clinic with Roswell Park but if TLT can really activate it with x-ray...

[Eoganacht]

Thanks for that enrique and Jaro. I saw Jaro's question on the chat about why they are using  TLD1433, but it wasn't answered. It sounds like they are working with rats now, using tiny versions of the OSA that they made. Hopefully there will be a phase 1b for IO-PDT for NSCLC using TLD1433 in 2021. The talk by Dr. Lilge updating the Theralase phase 1 & 2 trials at the Russian

[Longholder99]

Awesome. Thanks Enrique.