Theralase Technologies Inc. V.TLT

GBM

[fredgoodwinson]

https://theralase.com/theralase-lead-anti-cancer-drug-effective-in-the-destruction-of-brain-cancer-when-activated-by-x-rays/

 

Just a reminder that well over 3 years`ago Theralase highlighted the realistic possibility of the non-invasive destruction of brain tumour.

 

Might they now tell us that this is indeed the chosen route and provide us with a timetable to human trials?

[Hankerchief]

Fred,  This is amazing stuff IMO.  Just can't believe they have not been able to advance this treatment for three years.  Could have helped a lot of folks.

[CancerSlayer]

  Agree, it's been a long time Hank...Bypassing high-risk surgery would certainly be the way to go for GBM.  However, activation by basic x-ray or other form of external radiation is constantly evolving, which could partially explain the 3 year delay imo.  Though x-ray led to an excellent 75% tumor destruction preclinically, using more targeted or high-resolution/3-D imaging

[fredgoodwinson]

Theralase aren’t the only biotechs and - thank goodness - new treatments are already improving prospects for those with GBM and other until recently difficult-to-treat cancers. Hopefully Roswell Park and TLD-1433/Digilum will shortly be added to the list.   If they could do it with Rutherrin and x-ray though it would be so greatly less involved and  more humane - like something out

[menoalittle]

>> like something out of Science Fiction. Elysium, no doubt. (skip the adds, but note the 1:00 mark in this trailer) https://youtu.be/hvGE2nP4ga8?t=53

[fredgoodwinson]

Yup - that`s the idea!

[Pandora]

Didn't see anything relevant but maybe it's part of the audio. Can you give a hint as to what one is looking for? or listening for?

[menoalittle]

oh yeah, it's definitely part of the audio.  (evidently gets missed completely without it) the girl in red, lying on the table? gets a body scan... (elaborated on in the actual movie. this is only a brief snapshot of it.) the audio after... "cancer cells removed" the visual on the screen then reads "100% clear"

[TriumphSpitSix]

Elysium debuted in 2013. Less than 10 years later and we're turning science-fiction into science-fact.

[menoalittle]

okay, dug around and found it again. always worth a reminder of how just close to reality science fiction often times turns out to be... __________________ (skip the adds, but note the 1:00 mark in this trailer) https://youtu.be/hvGE2nP4ga8?t=53 and it's definitely part of the audio.  (evidently gets missed completely without it) the girl in red, lying on the table? gets a body scan..

[Eoganacht]

Hi Fred - as of Dec. 15 Shawn Shirazi was suggesting Fall of 2021 for GBM and NSCLC phase 1 trials. He didn't mention any details about the procedures though.

[fredgoodwinson]

Thanks Hank & Eog.My post didn`t read well as am actually not impatient  but can only imagine the impact when a wider public fully appreciates that for diseases currently with the bleakest prognoses and necessarily radical surgical procedures such as GBM (and possibly NSCLC???) it may prove possible to treat non-invasively via an intravenous injection and low dose exogenous x-ray. The

[menoalittle]

Anything further said about using TLD-1633(+ transferrin) for it, or is there still too long a runway for this "newer and improved version of TLD-1433" to be ready for GBM trials?

[jicoop]

I've been asking about this for some time as well. Remeber this news release, over 3 years ago, so what happened since ?  Excerpt below. Also, I am encorgaed by the US sites coming on board, the Phildelphia sites are very promising, as they encompass multiple loactions in the greater Phili area, where by contract , the Myrtle Beach clinic seems like a small mom and pop shop , excuse the

[fredgoodwinson]

Yes that`s a real puzzle re.TLD-1633.

[tamarindo1]

Taken from an old discussion on transition metal complexes & PDT. Considering the potency of TLD1633, it may seem odd that TLD1433 was selected instead. TLD1433 was prioritized over the other compound for a number of reasons, including: (1) there were more synthetic steps required for producing TLD1633, and those steps were low yielding (unoptimized at that time) and required expensive

[fredgoodwinson]

Thanks tamarindo - a direct explanation.