Theralase Technologies Inc. V.TLT

Theralase current status

[NorCalTommy]

Sorry i haven't been following the message board for awhile but love the TLT story, recently had a big position and hopefully buying back soon... I came across your post Eoganacht... and i found myself wondering if the Theralase story is still as exciting and ready to pop, with the obstacles you mention below regarding Photosensitizer uptake... is this considered a new discovery, did they not know this all along? Is TLT running into obstacles and conditions that they had not completely considered and factored into their therapy, or am i just making too much out of this excerpt below? Is it going to take a host of different applications/procedures by TLT instead of a much more defined and 2x per year frequency treatement that seemed uber elegant and very simple..... now it appears that there are lots of variables....  but again i am not close to expert on these therapies... so i would be very interested in your take (Fred, Cancer Slayer, EOG, and the 'extremely knowledgeable crowd') on how you believe TLT is currently doing?  are they 'on plan' or in the middle of 'course corrections/mods/revs' to make the PDT treatment more effective??

Thanks immensely in advance!!

EOGANACHT's Post Excerpt:


It’s acknowledged that the inter- and intra-patient variability of the tissue optical properties and the photosensitizer uptake remains a major obstacle to fully exploit the dual selectivity of PDT, resulting even with the application of precision PDT treatment planning in highly variable treatment outcomes. Enabling personalized PDT treatment planning requires the ability to quantify or predict the locally variable tissue optical properties, photosensitizer accumulation and oxygen availability

[fredgoodwinson]

The last person to ask on such matters NorCal and defer both to those from a medical background who we are lucky to have as contributors here and to those who research as thoroughly as does Eoganacht.   Like you his suggestion that NIR PDT will likely be required in addition to the Rutherrin/ low dose x-ray combination was news to me though this possibility was left open by the wording of

[Eoganacht]

I think Theralase is doing great and that we will be happy with the phase 2 results despite the false start. Dr. Lilge is a perfectionist and is doing everything in his power to optimize the treatment. He keeps pushing because "good enough" is just not part of his vocabulary.

[Yajne]

Eogan, is it fair to say that your highlighted comments relate primarily to future indications (i.e. GBM) that will use radiation followed by NIR? I have assumed that NMIBC stage2 trial has not deviated from the original treatment plan. Here is description from TLT website for GBM where dual activation is clearly the treatment plan: Advantages of TLD-1433: Stable under radiation activation

[Yajne]

Also great to see that under ACT tab they are describing both GBM and NSCLC as "late preclinical". Expect that further details shared about status of these at the upcoming AGM. What does "late preclinical" really mean in terms of timing to kick off Ph1b trials?

[StevenBirch]

My guess is once they make their NMIBC submission to the FDA we could get news on that. They did say when Phase II was 'well underway' so I think that would qualify. 

[Eoganacht]

I think so, even though Dr. Lilge is writing here about precision PDT treatment planning in general, it's applicable to Theralase's treatments.

[Longholder99]

The new standard of care for many types of cancer in the near future....and Lothar Lilge knows it. Ive been continuing to accumulate. Many thanks to the strong contributors here.

[Eoganacht]

Dr. Lilge is part of the team trying to make this happen. His research focus is on making oncological photodynamic therapy in general more practical and effective. And right now Theralase is the only game in town.

[CancerSlayer]

  Yes...imo, we couldn't have anyone more qualified than Dr. Lilge to simplify/perfect TLT's PDT approach, which is an ongoing process for sure.  However, visible/NIR light PDT will always have its physical/tissue depth limitations, necessitating the development of interstitial light-delivery strategies to address the more deep-seated tumors.  Found this abstract looking

[fredgoodwinson]

Thanks CS - Eoganacht mentioned that Prof.McFarland had suggested the possibility of down-converting x-ray photons to visible light photons in such a way and it is encouraging to think that she may be working with Dr.Lilge on this right now.

[CancerSlayer]

  To be clear...a high-Z element may include metallic elements other than Ruthenium.  It was not my intention to infer that Ruthenium was used in the above referenced study.  My statement re: combining a scintillator with a photosensitizer (like TLD-1433) into a single nanocarrier/sphere was based on theoretical interest only.  I am not claiming it has been done or that there

[99942Apophis]

CancerSlayer wrote  To be clear...a high-Z element may include metallic elements other than Ruthenium.  It was not my intention to infer that Ruthenium was used in the above referenced study.  My statement re: combining a scintillator with a photosensitizer (like TLD-1433) into a single nanocarrier/sphere was based on theoretical interest only.  I am not claiming it has been

[Eoganacht]

Yes, we don't know which way Theralase is going to go with this. It seems that X-Rays by themselves can activate Rutherrin better than they can most photosensitizers. There has been work going on trying to improve X-PDT with nanoscintillators for more than 10 years, but this has been with inferior photosensitizers. Nanoscintillator-Mediated X-Ray Induced Photodynamic Therapy for Deep-Seated

[CancerSlayer]

Eoganacht wrote: "Yes, we don't know which way Theralase is going to go with this. It seems that X-Rays by themselves can activate Rutherrin better than they can most photosensitizers. There has been work going on trying to improve X-PDT with nanoscintillators for more than 10 years, but this has been with inferior photosensitizers."   Until the use of nano scintillation

[NorCalTommy]

Thanks much for your input Eoganacht!  comforting indeed.....  just a matter of waiting    NCT