Theralase Technologies Inc. V.TLT

New Online Ad from Bladder Cancer Advocacy Network

[Eoganacht]

There is a need for more options in non-muscle invasive bladder cancer (NMIBC) when BCG fails

Bacillus Calmette-Gurin (BCG) has remained the first-line standard of care for more than 40 years

- Though BCG can be initially effective in the first-line treatment of high-risk NMIBC, BCG will fail in more than 40% of patients

- When BCG fails, high-risk patients are more likely to progress to muscle-invasive diseases, bringing them one step closer to life-altering radical cystectomy

"The limited number of patients studied in these [therapeutic] trials, the modest and limited recurrence-free survival with treatment, and the lack of data demonstrating an improvement in progression-free survival illustrate the need for novel agents.

 

– AUA/SUO Guideline"

[CancerSlayer]

  Thanks Eoganacht...& unfortunately, patients will have to continue to contend with an ongoing BCG shortage that could last for at least several more years.  I believe Merck is planning to have a new manufacturing facility completed in Durham, NC by ~2026/2027.   It's boggling to me that in this modern era of Western technology & proclaimed humanity by the West that

[Eoganacht]

It would be great to see a trial of TLD1433 as a first-line treatment of NMIBC after TURBT. Hopefully it would perform better than the 60% of patients who are responsive to BCG. It would certainly outdo BCG in patient friendliness. Maybe one day...

[fredgoodwinson]

Bemoaned the fact that this wasn`t the original Trial to start with on here at the time Eog while further expressing the view that the Trial as structured presented the potential for less than clear outcomes. Have perhaps been vindicated there - to date anyway.

[Rumpl3StiltSkin]

Just my opinion, IF this Phase 2 gets as many as 50/60 patients treated before a halt, again IMO. I think the CR %s will be up into the 70s/80s. Wont many Docs simply prescribe this as first line SoC off label? Many less treatments for the patient, easy to sell to them if it is more effective as well. ;-)

[Oilminerdeluxe]

Sounds perfect.

[CancerSlayer]

  Hi Rumpl....there is no law or medical community rule that requires doctors to always begin treatment with the first-line option.  Considering recent advances made in personalized medicine & the fact that first-line therapies can have their limitations/drawbacks (low efficacy, high cost, limited drug availability, increased side effects, etc.), demand for other suitable options

[Rumpl3StiltSkin]

Thanks Slayer, I agree this wont happen overnight, still, I think because we are talking about elderly, mostly, patients here, we will eventually get a healthy % of Docs reccomending this as an experimental option.

[Pandora]

Yes, if only the compassion for the loss of human life had 20% of the influence that the money trail has we would be much better off. Big pharma, big government and big activists have too much control over where priorities go. Therefore things take forever and a day.