Theralase Technologies Inc. V.TLT

An article on lung cancer

[11Familyguy11]

It's a year old, but the work they are doing on figuring out how to treat lung cancer is alive and well. Hopefully we will have a breakthrough one day and Theralase can contribute greatly to curing lung cancer.

https://res.mdpi.com/d_attachment/pharmaceuticals/pharmaceuticals-13-00137/article_deploy/pharmaceuticals-13-00137-v2.pdf

[fredgoodwinson]

Yes FG - why didn’t Roswell run with TLD-1433 in those Trials? Did Theralase refuse them the licence? Are TLT themselves being denied use of the sensitisers licenced to them but developed by Sherri on US campuses? Is there some sort of stand off here to the benefit of Big Pharma?  

[tdon1229]

  My vague recollection (I'm not as old as Pandora, but I might be gaining on him) is that Roswell was using Photofrin and someone else's laser in a clinical trial.  They were going to continue with those while retaining the option to include another arm with TLD1433 or some other alternate PDT of their own choosing.  Can anyone confirm or correct?

[99942Apophis]

That sounds correct tdon1229  my thought at the time was they were hoping the Photofrin in a new and improved version would be equal to or in the same Roswell Park (pun)  as the Theralase product. It still is my opinion that they didn't want a competitive product to outshine theirs. 

[CancerSlayer]

Hi Apophis....Porfirmer sodium is no longer patent protected & I can't imagine Photofrin is a big money maker for Roswell at this point.  Why else would Roswell agree to participate in an in vitro study of TLD 1433 other than to basically find a better option to the limited first generation PS (Photofrin).  The very positive in vitro results of TLD 1433 (& likely its future

[Oilminerdeluxe]

We deserve a good freaking update. Will we get it? Not sure. Maybe. But any positive word on virus and GBM and patients treated will feel good. Comparing my other holdings, Theralase is a beacon of stability these days. 

[99942Apophis]

CancerSlayer wrote Hi Apophis....Porfirmer sodium is no longer patent protected & I can't imagine Photofrin is a big money maker for Roswell at this point.  Why else would Roswell agree to participate in an in vitro study of TLD 1433 other than to basically find a better option to the limited first generation PS (Photofrin).  The very positive in vitro results of TLD 1433

[Eoganacht]

Roswell Park is sponsoring two intraoperative NSCLC pdt phase 1 clinical trials with photofrin and light delivery with Lumeda's licensed optical surface applicator. Research conducted by Roswell Park researchers in collaboration with Dr. McFarland of this procedure (intraoperative pdt of NSCLC) with TLD-1433 led us to believe that TLD1433 was being considered for a phase 1 clinical trial. 

[tdon1229]

Thanks for the confirmations ... I blanked on Lumeda, but otherwise Pandora's lead remains intact. ;-)

[fredgoodwinson]

The basis for my thinking is a puzzlement as to why having had Rutherrin -  a self-evidently superior compound to TLD-1433 in terms of safety efficacy and applicability - for over 6 years` they are only now going through the non-GLP and GLP investigations which have always been essential precursors to its` use in human Trials?   The most obvious answer is that for a long time they