Theralase Technologies Inc. V.TLT

Rutherrin

[fredgoodwinson]

Newsletter of Q3 2020:

‘Theralase® has completed one animal model and is diligently working to complete the second animal model. If successful, Theralase® will commence GLP toxicology studies in 2Q2021 with an aim to commencing a Phase Ib clinical study in GBM and NSCLC in 4Q2021.’

 

Newsletter of 4Q 2020:

 

‘Theralase® has completed one animal model and is working to complete the second animal model. If successful, Theralase® plans to commence a GLP toxicology studies with an aim to commencing a Phase Ib clinical study in GBM and NSCLC in 2022.’

(minor date slippage - par for the course)

 

Newsletter of Q1 2021:

 

Once Rutherrin®’s Maximum Tolerated Dose (“MTD”) and hence Human Equivalent Dose (“HED”) limits have been determined through non-Good Laboratory Practices (“GLP”) and GLP toxicology studies, Theralase® plans to inject Rutherrin® systemically into patients via a Phase Ib clinical study, planned for 2022, to allow localization to various cancer cells, including GlioBlastoma Multiforme (“GBM”) and Non-Small Cell Lung Cancer (“NSCLC”) and then activate Rutherrin® with radiation to safely and effectively, destroy the cancer of interest.

 

Newsletter of Q2 2021:

 

Strategic objectives

 

2. Successful completion of non-Good Laboratory Practices (“GLP”) and GLP toxicology studies to allow regulatory approval and commencement of a Phase Ib clinical study for Glio Blastoma Multiforme (“GBM”) and Non-Small Cell Lung Cancer (“NSCLC”).

 

(getting vaguer- no timelines anymore!)

 

More recent Newsletter dated the 7th of February 2022:

 

Currently in development of an injectable form of TLD-1433 (TLD-1433 + Transferrin = Rutherrin®) for additional cancer indications; specifically, Non-Small Cell Lung Cancer (“NSCLC”).

 

(Timeline gone - GBM removed - whatever happened to GLP?)

 

Enrique`s post of the 12th of April 2022:

 

‘After speaking with Dr Mandel, he let me know that the Company was very satisfied with the results and they were fully focused on this PH2 trial.’

 

Not this year for Rutherrin? Next year? Sometime? Never? 

The prospect of an amenable affordable effective and disruptive treatment to address human suffering on an epic scale looks to be receding ever further into the distance. Out of all that Sherri has developed Rutherrin was my great hope for TLT in that it was ‘clean’ IP entirely unconnected to her subsequent work in the States.

Is it dead in the water? If so maybe the market ain’t being so stupid here.

[Pandora]

Fred, I'm out of my depth here but would this patent application be at all related to the procedure you are referring to i.e. the Glioblastoma:

[fredgoodwinson]

That`s an awful thing with the School Pandora - and as to the patent wouldn`t have a clue as to whether it might be something that they`re waiting for or whether the withdrawal our Drug from prospective Clinical Investigation in GBM is the consequence of a particular aspect of Rutherrin antagonistic to the brain but sadly it seems clear that whatever options prove to be available to those

[Pandora]

https://www.ndtv.com/world-news/over-100-former-students-staff-of-new-jersey-school-get-rare-cancer-probe-launched-2890327

[patience69]

Yes it is frustrating. I am not by any means excusing their lack of transparency or anything like that but.. I wonder if management really even cares about the share price. They continue to make large salaries & theoretically at least the value of the company continues to increase. Maybe that is the only metric that really matters. Why quibble over a dollar or 2 in share price when already

[fredgoodwinson]

Somewhere between hope and wishful thinking Patience? - I`m the same as it’s the nearest we’re being allowed to get but can`t see anything paternalistic or benevolent in this silence.   We wait to learn whether TLD-1433 has any advantage over its’ competitors in NMIBC while knowing that in truth what separates Theralase from a host of other moderately promising biotechs is a stated

[Gooseybear]

Well spoken. I wonder if TLTFF has a competent Board of Directors or just some hand picked yes men and women.

[langosta]

I only have a couple of hundred thousand shares and although I will retain them I have completely written this monster off. Fortunately  at my advanced years it doesn't really matter.  I will have a codicil attached to my will leaving them to a grandson. I can picture him saying, " I wonder why Grandad hung on to a bunch of 0.02 cent shares, oh well I can prbably purchase a

[Marco321]

With a new target price of $1.20 from Research Capital I am not sure that I understand your comments.  Things are definitely looking better than ever, even if it doesn't feel that way in this difficult and risk-adverse macro market environment. All in my opinion.

[patience69]

I guess Marco what I am referring to or perhaps hoping for is that often times buy ins or buy outs can happen for a much higher price than the current market value. Once the market gets the sniff of a deal the price can catapult & then still sell for higher than share price so under those circumstances share price is less of a factor

[LaserStock29]

Round and round we just keep saying the same thing for eternia.... 8 years talking about buyouts and market 'sniffing' and catapulting. https://www.fiercebiotech.com/biotech/asco-novartis-backs-up-endocyte-buyout-prostate-cancer-data Endocyte's first offer from Novartis was $12 then a 10 month negotiation was doubled to $24.. so really.. when do u think negotiations happen here

[patience69]

Fred Do you think that (nobody knows) the reason that Roswell is not using 1433 is a lack of cooperation from us? Could it have been a business decision on our part?  It is frustrating that we have to guess our way around things!

[greaterfoolFred]

Maybe the reason that they are not using 1433 is that they would have to get an IND which requires GLP studies.  Theralase doesn't seem able to get around to this, so why would someone else do it for a drug they don't own?

[fredgoodwinson]

Exactly that Patience - we`re left guessing for want of information.If it wasn`t for Roswell Park themselves we wouldn`t know that they`d been interested even now.   With our own clear run to the Clinic a business decision to deny Roswell right of use might have made sense as our purported ability to activate Rutherrin by external X-ray (one of a number of areas in which it is said to

[patience69]

Thanks to all for this informative discussion although we can talk all we want & all we seem to get are more questions. More puzzles. I think that we are all getting frustrated here

[LaserStock29]

When is the Annual report due out? 

[Legit62]

all this  talk does nothing but get people nervous, the science is excellent up to this point in time and time will tell whether we get the BTD, hopefully end of month we get a quartery and financials, and possibly more good dicipherable data. Buying more and staying LONG

[Sunvalley]

Well said Legit62.We can talk and complain till the cows come home but all that will accomplish is a lot of foaming at the mouth and then the self doubt starts and the dark thoughts take root until a person finally starts wondering why they were even born. The shorts and the so called "market Makers" love it when there is squabbling and derision on a board as it causes selling and

[fredgoodwinson]

Never posted off-topic and make no apologies for persisting with this one.   Is it not understood here that in the Fall of 2020 we were given a firm (Q4 2021) intended start for 2 small cheap and quick Phase IB Clinical Trials which through mere proof of principle would have stuck a zero on the dollar share price value of anything that a successful NMIBC Trial will be likely to achieve?

[Oilminerdeluxe]

That's good question for the AGM. I think it was 6 or 7 years ago I bought TLT for the first time. It is lower today than back then. Ugh! One would think that if the results next update are better than the recent update, that they could somehow point that out in writing, so even feeble people like me understands it. Could bring a boost just by being clear. I have a sneaking suspicion they

[fredgoodwinson]

No intention to impugn fellow posters OM many if not most of whom have far greater knowledge/expertise in this area than I do - and that includes you!   Continue to doubt though whether unquestioning patience is any sort of virtue in the world of small biotech where value can (and quite suddenly) be diminished or even destroyed by the progress of others?   This from today’s press

[Oilminerdeluxe]

Fingers crossed for an exciting future. Perhaps we need that BTD before anything marvelous happens. But it seems within the realm of possibility we will have it one day. I would like them to talk about it more than they do, but perhaps they will soon.

[CancerSlayer]

  Hi Fred... This stressful world of small biotech investing is certainly not for the faint of heart or impatient.  There's always that painful paradox awaiting when I try to rationally base my patience on data/logic...yet without a healthy dose of patience, one will inevitably lack the necessary data/logic.  The pain only heightens when data trends take forever and a day

[fredgoodwinson]

Hi CS yes agreed and actually quite confident in the NMIBC Trial on the basis that if we didn`t have the goods Dr.Vera would not have come on board. It`s the Blue Sky stuff (treatment of non-superficial tumours) that has gone significantly awry. Everything was suggestive of this happening  - until it didn`t. Maybe I`m over-stating the potential impact of TLT announcing a successful non

[patience69]

Fred No need to feel alone on the lung cancer questions. I for one have many times pondered what happened with the Roswell trial. Maybe it was a business decision on TLT's part. Maybe an upcoming partner wanted it all. Maybe our xray activation is so supreme that we would be competing with ourselves?  Your points are valid . Why do we have to guess?

[fredgoodwinson]

Thanks Patience - that`s pretty much all I`m saying in a nutshell!

[CancerSlayer]

  Agree patience...it seems Roswell wanted to improve performance by using someone else's battery with our new engine.  They forgot we're not in the "parts" business ; ).  

[Infinity]

Fredgoodwinson,  There is no question, that we have a very viable product with huge potential to cure or mitigate a major cancer.  The Management by choice fail to communicate this and witholds major developments, blatantly put out confusing data that can be interpreted in many ways.   If they continue to take the share holders for granted, they will pay a heavy price in the

[robertshaw]

Completely agree. More than 8 years much promise yet less carry out, the only trustworthy side is science... That's the only reason most people are still here

[fredgoodwinson]

Yes Infinity and RS - it may be difficult for some to appreciate quite what a dismal experience this has been for retail shareholders over the years.

[floatinketucky]

Good afternoon fredgoodwinson, I always enjoyed considering things with you hope you are having a good day...  I threw in some .02 cents and change...   cheers!

[fredgoodwinson]

Afternoon Float and a very Happy Easter to you. Note and appreciate your comments on my previous post. Regards, Fred

[LaserStock29]

2014 Dec 31   Market Cap 66m  OS 85m (roughly) 2022 Apr 16    Market Cap 65m  OS 200m (roughly) 2019 the Private Placement right after the AGM.... overbought.. enough capital raise to cover everything until the end of Phase 2...... no further raise required.   The value of the company hasn't improved in 8 years.....  so yeah.. would be nice to get

[patience69]

Laser I certainly see your point in how the market cao has not increased in that long time frame. My point albeit right or wrong is that has the value of the company to say Merck or Roche etc increased with the progress on the trial? Increased in a way not reflected in stock value as we get closer to BTD & possible approval?

[floatinketucky]

They have CA (Colllabroative Agreeement) and do not control the information they can release. Check the old PR for the "Today theralase was able to report" kinda clause. 

[floatinketucky]

The other side of the coin is things are going well and with CRs they are not authorized to do PRs.. And  Considering consequenses of resoved AE vs the fllip of a coin chance to keep ones bladder..... Insider buying has began again...   buyer bashers are around. Yet what is the cop doing???  well the market is sayin something...