Theralase Technologies Inc. V.TLT

Ru Complexes as Promising Candidates against Lung Cancer

[ScienceFirst]

Encouraging.  Devil's into details, but we have a proper metal.  We're not specified though in table 1 because we're still not in trial.

Very interesting paper.

Review - 2021

Ruthenium Complexes as Promising Candidates against Lung Cancer

Abstract: Lung cancer is one of the most common malignancies with the highest mortality rate and the second-highest incidence rate after breast cancer, posing a serious threat to human health. The accidental discovery of the antitumor properties of cisplatin in the early 1960s aroused a growing interest in metal-based compounds for cancer treatment. However, the clinical application of cisplatin is limited by serious side effects and drug resistance. Therefore, other transition metal complexes have been developed for the treatment of different malignant cancers. Among them, Ru(II/III)-based complexes have emerged as promising anticancer drug candidates due to their potential anticancer properties and selective cytotoxic activity. In this review, we summarized the latest developments of Ru(II/III) complexes against lung cancer, focusing mainly on the mechanisms of their biological activities, including induction of apoptosis, necroptosis, autophagy, cell cycle arrest, inhibition of cell proliferation, and invasion and metastasis of lung cancer cells.


Keywords: Ruthenium complexes; lung cancer


Table 1. Ruthenium complexes as promising candidates against lung cancer.

Figure 3. Structures of promising Ru(III) complexes inducing cell apoptosis

2.2 - Anti-Metastasis

Figure 4. Structures of promising Ru(III) complexes inhibiting tumor metastasis

3. Ru(II) Complexes

Figure 5. Structures of promising Ru(II) arene complexes inducing cell apoptosis

Figure 6. Structures of promising Ru(II) complexes inducing cell apoptosis


Figure 8. Structures of promising Ru(II) complexes inducing cell necroptosis
Figure 7. Structures of promising Ru(II) complexes inducing cell apoptosis and autophagy

etc ...

[Mitote77]

Great find thanks 

[ScienceFirst]

We're on the right side of the fence.  We can see it with the NMIBC trial results so far and the fact that TLT is also aiming at lung cancer (NSCLC) with Rutherrin (TLD-1433 + transferrin). Ru Complexes as Promising Candidates against Lung Cancer 4. Conclusions/Discussions Lung cancer remains a life-threatening malignancy due to poor prognosis and drug resistance, which is one of the

[fredgoodwinson]

Just seems a shame - and particularly for those afflicted in the context of a Roswell/Lumeda Trial that might have taken place by now - that they seem to have encountered issues of deliverability.

[patience69]

Hi Fred So just curious have you actually found the illusive reason why the Roswell trial did not take place?

[fredgoodwinson]

Not a clue TBH patience - and if it wasn`t for the vigilance of our most useful poster we`d never have known Roswell were interested and TLT probably wish we hadn`t as to my knowledge they`ve never even mentioned it.

[patience69]

There is no doubt in my mind that we were not supposed to know that. Guess that it will remain a puzzle !