Theralase Technologies Inc. V.TLT

Just Phase 2 results - 35 patients

[Eoganacht]

I rejigged the latest data (April 29) a little bit. I'm not sure if an Excel cut and paste will work but I'll give it a try. I took just the 35 patients from the phase 2 trial, eliminating 2 CR's (patients 5 & 6 from phase 1) and 1 NR (patient 4 from phase 1) I think things are looking pretty good. There is still a possible CR rate of 63% at 450 days. It all depends on the 450 day assessments of the 17 pending patients (plus a favourable ruling on the 2 PR patients).

Assessment	Patient Assessment Visit
	90	180	270	360	450
Complete Response ("CR")	15 (42.8%)	12 (34.3%)	7 (20.0%)	3 (8.6%)	3 (8.6%)
Partial Response ("PR")	6	6	2	3	2
Pending	3	8	15	17	17
No Response ("NR")	11	9	11	12	13
CR (Evaluable Patients)	46.90%	44.40%	35%	16.70%	16.70%
CR Potential	68.60%	74.30%	68.60%	65.70%	62.80%
Patients Treated	35	35	35	35	35

[Rumpl3StiltSkin]

And this is still including the non-optimized first dozen patients? Right? So I think the market will take that into consideration, also. In time. 

[Eoganacht]

Right!

[Pandora]

Eoganacht I wonder if you can give some discussion re the NR category. 13 out of 35 is a 37% rating. How does this compare to others, or to expectations. I do not recall what the number of NR's there were in the 6 patients of Phase 1b. Is there any particular factor(s) that you have derived which might be behind this incidence of "no response". I know the CR is the critical

[Eoganacht]

Hi Pandora - I think the majority of the NR patients are the first 12 undertreated patients.

[Pandora]

Thanks Eoganacht -- haven't noticed if that is a clarifying point that is included in the reports. We'll have to see how the next report comes out. In my opinion it would be a positive to clarify it as opposed to having people just see 37% NR.

[ScienceFirst]

Eoganacht ... What your CR potential numbers show is not only high numbers (60%-75%), despite 12 underdosed patients, but also quite consistent efficacy numbers, no matter the category (90, 180, 270, 360, 450).   And this consistency confirms that our technology destroys instantly, instead of just shrinking the tumors.  This is huge!

[BlueFranky]

Science, that might be your most compelling post yet!