Theralase Technologies Inc. V.TLT

60% of the road = 270-days

[ScienceFirst]

270-day data is 60% of 450-day data.  

August 31, we will have 270-day data on 11 more patients.  That will make our durable target statistically more and more significant.

[fredgoodwinson]

Yes agree August 31st - the 50 day-away dateline mentioned in my last post when the evidence should at last leave little room for doubt.

[Eoganacht]

From CancerSlayer's post: A look at the performance of these new kids on the block:  12 month CR data for BCG unresponsive CIS.... Nadofaragene Firadenovec = 24% N-803 + BCG = 40% CG0070 (as a single-agent therapeutic) = 27.5% How will TLD1433 stack up?

[Camphikefish]

Looks like we need to come in at 25-30 % at a minimum with our 12 month CR data. Thoughts on our chances/probability?

[LaserStock29]

3/10 was known wayback 1993 photofrin 60% w damages to organ 2022 we better minimum be over 60%

[Rumpl3StiltSkin]

I believe since NMIBC, via instilations, is so in-exact. We might be doing pretty well with %s in the 40s or 50s. Maybe we get as high as the 60s after AA and the much higher numbers of patients. Solid tumor indications is I think where TLT could see very high percentages.  Of course the best thing about TLTs ACT is how safe and repeatable it is. Turning NRs to PRs to CRs. Sure, I wish some

[Oilminerdeluxe]

You guys with spreadsheets. How many patients have reported 270 and 360 days by now? And, if possible, are you able to tell how many of these have had the optmized treatment? If I am not mistaken there should be a bunch of optimized people in the next update at these points, whenever it comes. It could hopefully change the CR quite a bit.

[ScienceFirst]

Optimized patients: Post August 1, 2020

[ScienceFirst]

May 29, 2020 MD&A makes mention of 12 Ph. 2 patients treated August 28, 2020 MD&A makes mention of 12 Ph. 2 patients treated September 30, 2020 MD&A makes mention of 12 Ph. 2 patients treated April 28, 2021 MD&A makes mention of 18 Ph. 2 patients treated May 30, 2021 MD&A makes mention of 19 Ph. 2 patients treated August 30, 2021 MD&A makes

[Oilminerdeluxe]

Thank you!

[LaserStock29]

Why not just do the pp now. The world is just getting tougher now to live. Same terms as 2019 for canadians 1 + 1 warrant free trading. . We've already treated 41. 11 still eed 2nd treatment. Eoy is no.25 at 450 Our trial is over. The only way we should be treating is the next phase in usa with BTD and AA for the latter 80 patients. At a $2 pps

[ScienceFirst]

Strange thinking LS29. You were whining about a potential pp weeks ago while TLT management were clear about no po and while Roger and Kristina had invested 750K$ of their own money and now, you want a po @0.28$ before August 31 new set of data!!! TLT management know what they're doing and where they're heading.  And they have more insights than you.  Clinical data will dictate

[ScienceFirst]

Last week, Merck was able to pay 40G$ for SEAGEN, even though financing conditions are getting more challenging.  Big pharmas have enough liquidity if they know what we can bring them in terms of future revenues.

[IFlyTheUnicorn]

This post has been removed in accordance with Community Policy

[skys1]

Agree ScienceFirst, that sure was a strange statement by LS29.

[Rumpl3StiltSkin]

I'm certain that TLT wants to avoid another disastrous pp down at these levels, IF they can. Indeed, SP seems to have some of that already priced in. They did say at this recent AGM that they would need $$$ within 6th months. Based on not getting the SP up higher, raising their profile, jetting a jv or buyout, etc. This is probably the last bet I'll be making on TLT, that they will

[Eoganacht]

In his recent talk with Dr. Roupret, Dr Kamat said of the N803 plus BCG combined treatment, that the 12 month 40% CR results, "seem almost too good to be true with very low toxicity" And "clearly that is something that we're all excited about that has been filed with the fda and we're waiting to see if it gets approved." More and more data from our phase 2 will be

[CancerSlayer]

  Nice post Eoganacht... I always have to keep my eye on the forest for the trees when discussing TLT's transcending/versatile ACT & its value.  You could probably count on one hand the number of drugs/treatments under study (globally) that have the realistic potential to "effectively" & "safely" treat both a variety of infectious diseases as well as

[Yajne]

Great post CS. Your last line re: aerosols is thought provoking..yes it does seem that bigPharma are overlooking the fact that our airways are our line of first defense!! Cancerslayer wrote: Nice post Eoganacht... I always have to keep my eye on the forest for the trees when discussing TLT's transcending/versatile ACT & its value.  You could probably count on one hand the number

[CancerSlayer]

Hi Yajne...thanks.  All the currently approved commercial vaccines are systemically administered & completely bypass the airway.  The potential advantage of using an intranasal vaccine is that it can induce both airway/mucosal & systemic immunity (both antibody-mediated & cell-mediated).  It also has the additional advantage of ease of administration...no shot required

[Yajne]

Makes total sense CS! ...unless you are Pharma and deeply invested into 'the shot'. Aerosol is a new paradym in the C19 space...so many people with their blinders on. Hope you've shared your aerosol ideas with Dr Mandel at TLT.

[ibaru55]

This post has been removed in accordance with Community Policy

[Infinity]

Cancer Slayer, I am intrigued by your observation on nasal aerosol type treatment approach. This approach could very well be the break through in any virus (Corona, Zika or Sars..type) vaccine. It could raise the efficacy, potency and may be even the durability?. Many including myself are getting tired of simply repeating the vaccine based on scant information and data. Yajne, Thanks for

[Rumpl3StiltSkin]

Although I agree that this MoD is exciting, would work better/easier than shots, etc. I think TLT is already solidly on the AvantGarde track with their PDT cancer ACT. I say let them go the more traditional route with this, work with Canada Govt. Then down the line maybe explore this as a MoD for Viraii and Bacterium and certain cancer indications.

[ScienceFirst]

If nasal aerosol deliver more efficiency than shots, it would have been a long time ago that aerosol would have been brought to the forefront as it would have given a hedge to the pharma or biotech that would have  brought it. Pharmas already have aerosol for some indications but it is based on facts and science.  So if COVID-19 shots would have been the best efficient methods, it

[99942Apophis]

ScienceFirst wrote If nasal aerosol deliver more efficiency than shots, it would have been a long time ago that aerosol would have been brought to the forefront as it would have given a hedge to the pharma or biotech that would have  brought it. Pharmas already have aerosol for some indications but it is based on facts and science.  So if COVID-19 shots would have been the best

[Yajne]

I've had SF (aka Bencro) in my ignore pile so missed this. Did he really say that? For a guy I once considered a Brainiac, I probably need to reconsider after a wild-a$$ assumption like that about pharma. Maybe they were always on the highly profitable needle/shot delivery route, with no regard for aerosol. Apparently SF is not the brainiac he considers himself, but rather a sheep blindlly

[O12009]

So it must be time to pick a fight and drive the stock price down again. Will make for a good buying opportunity.  GLTA

[ScienceFirst]

Yajne ... You always say that: "I've had SF in my ignore pile so missed this." Like if we believed you. Still into plot theories? ____________   ScienceFirst(6589) User Actions   July 12, 2022 - 08:13 AM 144 Reads  Post# 34817355 RE:RE:RE:RE:RE:Theralase Is still Flying Under the Radar

[langosta]

Hands up everyone who can claim that they have never said anything that they have regretted.

[Rumpl3StiltSkin]

Hmm, things I shouldn't have said or things I regretted saying?? ;-)

[skier59]

I think many of us are in that boat ! Shame you can't delete a stupid post you regret. However, just to express my thought, Roger deserves to get back into his CEO chair. I've seen much worst things fly by without a scratch to the CEO at other companies. Roger created TLT, it's his vision, let him finish it with Pride and Conviction. This is finally coming down to the final few

[FGPstock]

Skier, we all do and say things that we regret. That is part of life and learning. But when you tell the world, your shareholders, potential investors, etc that you have FDA and Health Canada approval on something when you haven't even applied, that is willful fraud, in my opinion. It is pretty hard to get in trouble with the OSC. We all know roger is currently violating his settlement

[Lesalpes29]

Trouble maker from day 1. Be ready, we could see the price going down. A short position to cover. A real shame...

[Infinity]

FGP,  I am having difficulty understanding your point.   Both Shaun Shirazi and Kipton Lade are previous employees of TLT.  Their contracts were terminated with or without mutual consent.   EX- Managers can say what ever they want against the management without violating any of the terms of their NDA etc.. However, I have not come across any damaging statements from

[CAinPlap]

Would Roger have to wait until next AGM to be appointed CEO?

[livermore2]

Like Steve Jobs to Apple - would personally love to have Roger back!!!

[ScienceFirst]

CancerSlayer ... Th National Microbiology Laboratory (NML) is the one that has the best expertise to propose the best delivery method to Theralase, as per one of Dr. Kobasa's comment.

[Rumpl3StiltSkin]

True Eoga, at that point does TLT even do a PP? At that point they could do a JV or even get bought out? Many more options....

[CancerSlayer]

I don't see an early JV or buyout happening if TLT is at all interested in maximizing value for themselves or their shareholders.  There's just so much additional potential/value post NMIBC approval.  Considering we can get to ~$1 US post approval (? on this exchange), it would be a low-risk play imo to dilute by ~15% in order to build cash/R&D/commercial reserves &

[Rumpl3StiltSkin]

Well Slayer,  It might not happen that early. A JV deal on just NMIBC might be a good deal for TLT. There are other partial deals like that that could bring them some money. They said they have 6 mos of $$ left, Yet I think that is worse case? Assuming they don't get any SP boost for some reasons.  All they need is a boost above .50c and Oct warrants should come into play. Lots of

[Infinity]

Cancer Slayer,  Dilution to raise money would be an acceptable option.  However, prior to raising the money by PP or what ever means, I would like to see some positive news reports.  I believe, the management likes to keep things very quiet, even tend to under play positive news for reasons that is known only to them.  I for one can not wait till Roger gets back from the

[ScienceFirst]

Infinity ... Good points. JV deal would probably not be signed before Roger is reinstated as a CEO, after Feb. 2023.  He deserves to be back in that role, no doubt, given where he brought us (on the verge of a Breakthrough designation and next SOC). JV would bring upfront payment, avoiding the need for a pp.  Our Ph. 2 NMIBC data is worth approx. 600M$+ now, as per industry's

[FGPstock]

Bencro, what are you smoking today? y would anyone wnat roger back in power. the company has progressed more since he has been gone than all of the years he was in control.He still gets paid more in salary and options than any other employee. He has admitted to lying about finanacials, patents, etc for 10+ years. I am not sure that is the guy I want negotiating a deal w big pharma.

[skys1]

FGP, weather you, me, or the BODs like it or not, Roger was, is, and for at least the immediate future will be the CEO. That's why Shawn left, because 'Roger is making the decisions". The primarily why the Commission came down on him so hard was his being wildly loose with his guidance. However, he did make a major effort at PR with frequent interviews & PRs and such which is

[FGPstock]

skys1, if your statement is true that roger "is, was and in the immediate future" the CEO, which I believe is true and have spoken to shawn, Kipton Lade and the fomer IR team and they concurred Roger is running things in the background, the roger is clearly violating the terms of his settlement agreement. Why give the OSC more reason to pour water on a potential cancer cure, ego???

[skys1]

OK FGP, I'll enumerate a bit more of Roger's strengths. Many years ago after Bob M's write up, I did my DD on TLT. I became convinved of 1433's remarkable potential so I was very concerned about the strength of it's patent protection. Back then you could pick up the phone and speak to Roger anytime you desired. We had extensive conversations on Roger's extensive patent work

[Eoganacht]

I agree. Roger made some mistakes but the OSC way overreacted. It would be great if he's the one to bring this across the finish line. It will be an amazing achievement.

[FGPstock]

Eog, I don't think you should tell the world something has FDA and Health Canada Approval when it doesn't, that is outright fraud... overstating the financials projections for 10+/- years isn't too honorable imo either. I think the OSC went easy as, like skys1 said, roger is still the ceo...

[Longholder99]

I firmly believe our one and only CEO will.bring this home. ACT and C19. Once RDW is back in the left chair we will see whats what.

[ScienceFirst]

Look at our Bozo FGPSTOCK! The guy that thought bullet points missing in a corporate presentation was what made the stock drop at an opening! _____________ FGPstock - (7/15/2022 12:11:59 PM) RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:60% of the road = 270-days Bencro, what are you smoking today? y would anyone wnat roger back in power. the company has progressed more since

[FGPstock]

Ben, everything posted is 100% accurate. If tlt was on a real stock exchange there would b no way he would be allowed in any public company. We all know you don't have the ability to b objective as you are either Roger or he is your idle.

[ScienceFirst]

Poor little dickhead FGPstock!  Still rehasing negative propagenda.  We see into your agenda. You sound so much like our libertarian Bungee that was sued by TLT and that always had something negative to say about Roger. All CEOs have put their signatures at the bottom of official documents.  And none of them with a gun on their head.  So their signatures are officials and

[vladpanka]

This post has been removed in accordance with Community Policy

[99942Apophis]

Rumpl3StiltSkin wrote  I'm certain that TLT wants to avoid another disastrous pp down at these levels, IF they can. Indeed, SP seems to have some of that already priced in. They did say at this recent AGM that they would need $$$ within 6th months. Based on not getting the SP up higher, raising their profile, jetting a jv or buyout, etc. This is probably the last bet I'll be

[fredgoodwinson]

Good last 3 posts. We are a sitting duck untril the next set of Clinical results.

[Rumpl3StiltSkin]

Laser, whe we meet in Vegas. After this adventure is over, you'll have to bring along some of your stash, I'd like to sample some... ;-)