Theralase Technologies Inc. V.TLT

huh?

[riverrrow]

It looks like I have too many people on ignore.  I'm not seeing any new posts for the last 24 hours.  I suspect all the longterm shareholders are fully loaded and so are not buying anymore shares.  I'm not sure if there's anything that can drive the share price up before the next set of clinical results are released.  And so we wait again for another two and a half months.  GLTA.

[Scorpio2]

We could get news on the vaccine front anytime in October. But, the real biggie will be the Phase 2 ACT trial update anytime in December. 

[Eoganacht]

In December we should see the submission of the 450 day results for the first 25 patients. We already know the results for the first 24. Currently the 450 day CR rate is 21%. If the 25th patient is CR this will be a CR rate of 24% And if the 3 PR patients are converted to CR this will be a CR rate of 36%. These results, along with the better results of the patients who have not yet reached

[99942Apophis]

Hi Eoganacht patients 21-24 were announced August 30/2021 in receiving their primary treatment so they have only reached 360 days which would mean they along with patient 25 will then reach 450 by mid to end of December, if that's the case then the CR percent will be greater as those 5 represent 20% of the Phase2  population. My assumption here is when new patients are announced they have

[Yoly900]

This post has been removed in accordance with Community Policy

[Eoganacht]

Hi 99942Apophis - this chart is from the last MD&A (with the number of patients added) "An analysis of Evaluable Patients (defined as patients who have been evaluated by the principal investigator and thus excludes data pending), in Study II provides the following interim analysis (including three patients from the Phase Ib NMIBC Clinical Study treated at the Therapeutic Dose):"

[99942Apophis]

Sort of maybe could accept 21 as that patient would be on the cusp! I know from experience that in making a report its not done in a couple of days but is probably a few days to a week old so from the previous announcement done June 11/2021 for patient 20 then #21 still could have really been slightly before that say June 7 so that patient could have made the time slot of 450. So yes definitely 4

[Eoganacht]

I'm really hoping for that 40% CR at 450 days. If we get it we will have achieved the same CR rate at 450 days that Keytruda had at 90 days - and we would have achieved that with almost half of the 25 patients undertreated !

[99942Apophis]

I too am hoping for 40% and feel assured going forward beyond the 25 (28) ? that as we get closer to the 100-125 we will finish with a very respectable and applauded CR percentage. 

[Yoly900]

This post has been removed in accordance with Community Policy

[DJDawg]

My interpretation is similar. The way I visualize the numbers is that when you compare Aug to May: August: -4 CR patients arrived at 360d timepoint that were not there before - no NR patients arrived at 360d that were not there already - one PR was reduced, which likely means that a PR was converted to a CR on analysis. The means that there are 4 patients ready to make the leap to the next

[99942Apophis]

Hi Eoganacht it appears you're not the only one to have forgotten an important factor in patient count or in my case I awoke in the middle of the night remembering the basic trial end points that if memory is correct stipulates 7 days plus or minus at 90 days and thereafter it moves to 14 days plus or minus which would allow patients to fit into target end points. Eoganacht wrote Hi

[Yoly900]

This post has been removed in accordance with Community Policy

[Rumpl3StiltSkin]

40% Sounds great @ 450days to me. 1-2 treatments. Repeatable. Standalone... I do think they will include the 3 Phase1 patients who were given the larger dose. They have been including them so far..??

[Yoly900]

This post has been removed in accordance with Community Policy