Theralase Technologies Inc. V.TLT

New McFarland Labs Research of TLD1433 Processes

[Eoganacht]

Using Biological Photophysics to Map the Excited-State Topology of Molecular Photosensitizers for Photodynamic Therapy

Avinash Chettri, Tingxiang Yang, Houston D. Cole, Ge Shi, Colin G. Cameron, Sherri A. McFarland, Benjamin Dietzek-Ivansic

First published: 24 February 2023

Abstract

 

In this study, TLD1433 a Ru (II) complex, in human clinical trial in photodynamic therapy (PDT) serves as the benchmark to establish protocols for studying the excited-state dynamics of photosensitizers (PSs) in cellulo, in the local environment provided by human cancer cells. Very little is known about the excited-state properties of any PS in live cells, and for TLD1433, it is terra incognita. This contribution targets a general problem in phototherapy, which is how to interrogate the light-triggered, function-determining processes of the PSs in the relevant biological environment, and establishes methodological advances to study the ultrafast photoinduced processes in TLD1433 when taken up by MCF7 cells. We generalize the methodological developments and results in terms of molecular physics by applying them to TLD1433’s analogue TLD1633, making this study a benchmark to investigate the excited-state dynamics of phototoxic compounds in complex biological environment.

[CAinPlap]

We generalize the methodological developments and results in terms of molecular physics by applying them to TLD1433’s analogue TLD1633 What does this mean?

[BlueFranky]

I was wondering the same thing, CA.

[Eoganacht]

I think it means that they made sure their research doesn't just apply to TLD1433 by also using the PS TLD1633. TLD1633 is TLD1433's younger, more effective and safer brother. McFarland Labs continues ro use it in research even though TLD1433 was preferred for the NMIBC trial. In 2017 TLD1633 was found to be 15X more effective against gbm cells than TLD1433. In 2018  Dr. McFarland

[wildbird1]

CAinPLAP & BlueFranky... I am very far from being an expert on the subject... TLT already know that TLD-1433 kill cancer cells by Reactive Oxigen Specie(ROS). The above study seem to indicate that DrMcFarland and her team want to know more about the Mechanism Of Action(MOA) that trigger this killing process. The end result, could be the design of much more potent PDT. Good News.