Theralase Technologies Inc. V.TLT

Trial Result Tables

[Eoganacht]

Below are 3 trial result tables.None of the 3 tables include the phase 1 patients as it looks like Theralase will be presenting trial data without them from now on.

The first is from the ASCO presentation (29 Nov 22 results) but with the phase 1 patients removed.

The second is derived from the AUA presentation table and Swimmer's Plot. It includes the CR patients so that the ASCO results and AUA results can be compared.

The third is the same as the AUA table but with the first 12 undertreated patients removed. I believe this table most accurately reflects the efficacy of the treatment.

Assessed	90 Days		180 Days		270 Days		360 Days		350 Days
	%	#	%	#	%	#	%	#	%	#
CR	53%	21	43%	15	38%	13	26%	8	23%	6
IR	15%	6	26%	9	21%	7	16%	5	12%	3
TR	68%	27	69%	24	59%	20	42%	13	35%	9
NR	32%	13	31%	11	41%	14	58%	18	65%	17
Evaluable	40		35		34		31		26

Results from ASCO Presentation minus phase 1 patients

Assessed	90 Days		180 Days		270 Days		360 Days		350 Days
	%	#	%	#	%	#	%	#	%	#
CR	54%	28	49%	23	38%	15	24%	9	22%	8
IR	12%	6	17%	8	15%	6	5%	2	5%	2
TR	65%	34	66%	31	53%	21	29%	11	27%	10
NR	35%	18	34%	16	47%	19	71%	27	73%	27
Evaluable	52		47		40		38		37

Results from AUA Presentation including CR patients

Assessed	90 Days		180 Days		270 Days		360 Days		350 Days
	%	#	%	#	%	#	%	#	%	#
CR	70%	28	66%	23	54%	15	35%	9	32%	8
IR	15%	6	23%	8	21%	6	8%	2	8%	2
TR	85%	34	89%	31	75%	21	42%	11	40%	10
NR	15%	6	11%	4	25%	7	58%	15	60%	15
Evaluable	40		35		28		26		25

Results from AUA Presentation including CR patients with the 12 undertreated patients removed

[Infinity]

Thanks Eoga,   This presentation has way more clarity.  I believe the last column on the right has a Typo,  should read 450 days instead of 350 days?

[Eoganacht]

Yes it was a typo - it should be 450. Thanks Infinity.

[Rumpl3StiltSkin]

Really like this Eoga, Nice Job

[greaterfoolFred]

 Good effort Eoganacht, and I hate to sound negative, because I am not, but is it true that all of the first 12 were NR at 450 days? Someone posted earlier that 2 of them were CR.

[CancerSlayer]

  Thanks Eoganacht.... When I look at the 4/26 Swimmer plot, there are 13 active patients (at different stages) who have been assessed at 90 days, plan to move forward with the trial & are awaiting their 360 day assessment.  Interestingly, 2 patients who had CR through 90 & 180 days are represented as currently being inactive. For the above subgroup of 13 patients, 11 of 13

[Eoganacht]

Thanks CancerSlayer - I think it's looking very good. A durable complete response of 30%-40% along with only one or two one hour treatments and no safety issues bodes very well indeed.

[Rumpl3StiltSkin]

Does the 90 day data in the swimmers plot include the 2 CRs from phase 1? If not then I don't think there are 2 discounted CRs in the swim plot data. I don't think there were any  of the 12 undertreated that were CR? Maybe a few of them were IR? So IF I'm correct the worst we will have is that 35% 450 day CR  Slayer came up with. :-)

[enriquesuave]

In the initial 12 under treated, there were 3 CR patients and 3 PR patients at 90 days.  I can still see between 40-55% CR depending on how IR Patients are reclassified and also if new CRs appear after 2nd treatment when all is said and done.  Anything above 30% for only 2 treatments 6 months apart and minimal side effects is still way better than Keytruda and Adstiladrin or any other

[NotinKansas]

To identify the results achieved by the 12 initially undertreated one has to revisit the MD&A for full year 2021 (dated 28 April 2022). Here on page 5 they first present the results for all patients then treated, incl. those from Phase Ib (first table), and next the results for the optimized cohort alone, this time excl. Phase Ib (second table). If you deduct from the first table the two CRs

[Rumpl3StiltSkin]

I stand corrected from my post below. There were some CRs from the 12 undertreated. Which to my thinking is even more encouraging. Makes the removal of these numbers from overall study seem more fair.

[ScienceFirst]

Great digging NotinKansas.  Thanks for sharing.