Theralase Technologies Inc. V.TLT

Adstiladrin Five Year Data Is Out

[Eoganacht]

The 5 year Adstiladrin results are out. There are positive aspects to the treatment, but the 5 year complete response rate is not high. I take it that "high-grade recurrence-free" is the considered the equivalent of a "complete response", but expressing it this way makes me wonder if low grade cancer might still be present in one of more of these patients.

 

They are using the deceptive percentage of percentage presentation of data, but even this is quite low.

 

"In the CIS cohort, among patients who had a complete response at 3 months (n = 55), 10.9% (n = 6) remained high-grade recurrence-free (HGRF) at 57 months.

 

If you look at the entire 107 patient CIS cohort -  6 out of 107 were high -grade recurrence free at 5 years = 5.6%

 

 

https://www.urologytimes.com/view/nadofaragene-firadenovec-sustains-efficacy-in-nmibc-at-5-year-follow-up

[DJDawg]

Great share Eog. That boggles the mind. That many instillations to 107 patients and only 6 get to be considered home free of the cancer. Reading in more detail (although I find it confusing since two groupings) 107 CISTa/T1 50 CIS 3 month CR in CIS group was 55/107 = After 4 treatments, if still good, were offered to continue getting instillations every 3m 42 patients kept going past a year

[BlueFranky]

Thanks Eog.. great post! You just got to believe that the recent hires are  all hands on deck/nose to the grindstone, helping to smash us through the goal posts. GLTA!!

[Legit62]

My same thought BlueFrankey, no insider buys this last PP, something cooking, possible insider info prevented buys??? we should hear something hopefully in June