Theralase Technologies Inc. V.TLT

Come hell or high water

[2b7f6fab]

We have the best researchers as shown by this paragraph from the latest news release.

A possible explanation for why BCG works for certain patients, fails in others and lacks a durable response may lie in the fact that BCG possesses a strong negative electrical charge. Cancer cells also possess a strong negative electrical charge. This results in the formation of a repulsion between the BCG bacterium and bladder cancer cells, which would thus make it difficult for BCG to adhere to and be absorbed by bladder cancer cells to affect a response. As a result, BCG remains unable to securely bind to the target bladder cancer cells and thus is ineffective in their destruction. This charge repulsion between BCG and bladder cancer cells is demonstrated clinically, by patients being required to undergo multiple BCG induction treatments,

[plantrader]

So now will Merck say 'Hey thanks for the tip... we'll tweak BCG on our own so that it doesn't have a strong negative electrical charge anymore'. I have no idea if that's possible, but that would fit the pattern of unspoken letdowns.

[CancerSlayer]

Such a novel discovery would be patentable imo, & I'd be surprised if Theralase hasn't already addressed that concern.

[plantrader]

Yeah, it's hard to imagine them announcing it before doing so. I wonder why the news wouldn't mention it.

[Alamir1111]

We expect that the new Theralase® proprietary formulations will enable the optimization of various bacterial-mediated tumor immunotherapies to enhance their value in numerous clinical applications"

[Eoganacht]

I think Merck would be more likely to let us implement the tweak and then buy us out. Nowadays big pharma tends to let others do the groundwork so they can just reap the benefits by opening their fat wallets.

[Alamir1111]

I agree merck to tweak  bcg would require their own PDC  since tlt is patented.plus you would need a metal based compound which transmits electricity altough changing-to + So far Ru seems to be the most potent.

[skys1]

Yeah, I can't believe Merck wasn't shocked by this latest PR. I don't see how Merck (or someone else),  doesn't make a move on TLT fairly soon..

[menoalittle]

Quite frankly, I think the biggest reason (perhaps the only reason, at this point)  that a hostile takeover might have any real difficulty or resistance is the potential for it to trigger a bidding war.  

[CancerSlayer]

100% agree Eoganacht... Big Pharma also often lacks the internal knowledge to do the tweaking & it's simply cheaper for Pharma to acquire a small biotech than spend potentially years/many millions on R&D.   If you look at all of the coals we now have in the fire, I think we will be prime for the picking when/if we get BTD validation for NMIBC.  It's about time these

[CancerSlayer]

..."it's simply cheaper for Pharma to acquire a small biotech" In our case, substitute "easier" for cheaper.  This versatile tech shouldn't come cheap...

[plantrader]

@CS & Eog, great points, thanks. Yet here we are, the market has called BS on the news once again. Probably b/c of the pattern of only doing this right before fundings (promotion). But what the heck is going on... I can see how and why an upstart financially struggling company could have a discounted market cap, but this is ridiculous. Time to go back into lurk mode.

[menoalittle]

>>  Yet here we are, the market has called BS on the news once again.  mmmm.... seems I disagree.  We've taken an over 30% rise in only 5 days, on something less than 4 million shares (maybe less than 2% of the outstanding), most of which were sold for something over 18 cents, probably by those expecting a pp to cap the price and allow them to buy them back (one way

[plantrader]

Well Ok then, I get what you're insunuating. I must admit I like your impression better than mine. I hope in this case unomorethanalittle. 

[Kingpin68]

It does seem strange the stock price hasn't lost 2-3 cents after the recent spike. Maybe it means nothing though 

[plantrader]

It has. It hit a high of .21 a couple days ago, no? Now it's .19 but to your and noalittle's point so far the NRs haven't opened the door to a typical pattern of increased volume selling which usually ends up being the prelude to a PP.

[Kingpin68]

No, it never closed at .21, that was intra-day. Typically it would lose about half...it hasn't...yet

[plantrader]

True, it's holding up better so far than it usually does. But look at the chart around March 4th. It closed higher at the peak then vs now (instead of an intraday spike only) but then it consolidated for a few days before resuming downwards. Similar pattern so far right now, we just don't know how it'll end yet.

[menoalittle]

Well, I still think it wants to trade higher... so I took down a couple whacks of it.

[DJDawg]

I think anyone who has bought above 0.18-0.19 in the past 6m had wished that they waited for the PP announcement and then got in on that or bought at the lower price that always come with PP news. Until they show that a 0.18 pp is not coming, I suspect the price will be stalled in the current range.