Theralase Technologies Inc. V.TLT

3rd quarter

[Legit62]

3rd quarter next week, fingers crossed this is our promised quarter for RESULTS

[Alamir1111]

Maybe we get some uptade  on parkinson's  trial?

[Infinity]

Promised quarter sounds kind of familiar isn't it.   

[N0taP00p]

@infinity: sure does. It's always next quarter.   Q4/Q1 to Q1'24  to Q2'24 to now, Q3'24 submission. To my knowledge, and as mentioned by many here, no specifics ever given on why the pushouts are happening other than a  combination of possible factors. Have they ever explicitly said "this is the main reason we were not able to submit the pre-BTD

[plantrader]

Right now IMO one concern is that the "central pathology" analysis finds inconsistencies in how the tissue or data was analyzed previously as part of the results the company has been publishing thus far. Since we don't know exactly why the FDA appears to have added that requirement mid-stream, I think it's a legit concern. Receiving BTD will relieve all those types of ambiguous

[Donein25]

very good point. I raised this very issue at AGM. As you undoubtedly noticed the most recent data showed a 5% decrease in CR across the board. We may see more of this CR adjustment in the near term, but i think once patients are retreated after a recurrence, then these CR #s should rebound back.

[Eoganacht]

It's clearly not a concern as far as Roger is concerned. "...it was a bit of a surprise for us that they insisted on central pathology. Because the concordance level of local pathology compared to central pathology is extremely high - 95 to 100%. I think when I was talking to Doctor Peter Black, who runs the UBC site, he did a study for monoclonal antibody, I think Atiza was the drug

[Johnandrose22]

Thanks, as always, Eoganacht! My question arises from Mr. White's summary of local/central pathology and concordance and the accuracy of one to another.  Mr. White found the "ask" for central pathology oversight "weird". That term caught my attention. What is the weird, out of the ordinary part of of all this? Is TLT and it's process being singled out? Am I

[N0taP00p]

Good insights, Eoganacht.Took a look at LabCorp.com , page titled What Does A central Lab Do?   In this case, if the FDA requested them to take every result and replicate it at one of these labs,  there must be some concern about process variability across CSS sites, despite RDWs comments to the effect of being surprised by this ask.  The conspiracy theory types may blame "

[Eoganacht]

Hi John - maybe the FDA is just being extra careful with a non-mainstream NMIBC treatment type with a dubious past. Photofrin PDT was approved by HC for NMIBC in 1993 before it was recognized that it caused permanent damage to a significant proportion of patients, rendering them permanently incontinent. PDT for NMIBC was approved in the past when it should not have been and the FDA is certainly

[Johnandrose22]

Eoganacht....thank you. Your response puts Mr.White's words into wider context. Despite his apparent frustration, the CEO remains very confident. And so do I.

[plantrader]

@eog, Thanks. That is a little bit of potential assurance. But we can't exactly go by what the company thinks, since as RDW said the FDA calls the shots. Hopefully he's right in his perspective though.

[wildbird1]

Thanks Eoganacht..excellent post. Although R.White did find unusual the request for more central pathology data, at the same time R.White must have felt relieved and said to himself... Woow!!! That is all the FDA is asking for!!!(TLT Scientific Team Dr.Mandel &Co know that the pathology concordance is very high). By not asking TLT for something more complicated than double-checking TLT

[N0taP00p]

@wildbird: If you go back and look at  some of the Exuberant Gang  posts over the past 2 to 3 years, what are some common themes we see repeat?  Big pharma buyout coming. JV coming.   No more money or PPs needed.  BTD is coming soon.  You will regret not buying shares now....  and so on. And yet here we are.Groundhog day/month/quarter/year.  

[wildbird1]

notaPOOP, for your information... -3 years ago TLT didn't have 57 patients fully treated at 450 days. -3 years ago TLT didn't have a huge 37% TR(CR+PR) at 450 days. -3 years ago TLT didn't have a treatment that was superior to Valrubicin, keytruda, Adstiladrin, CG Oncology and N803+BCG. -3 years ago TLT didn't have a compound that could be used  to improve efficacy of

[BlueFranky]

Wildbird1 ... Excellent post  In fact.. I'm putting this front and center on my screen to remind me each morning, how close we are.

[Eoganacht]

Thanks wildbird1. Yes, we have lots of reasons to be optimistic. Longterm shareholders will remember the nail biting years when one question dominated everyone's minds. That question has now been answered with a resounding "Yes!" by hard data. Sooner or later the market will catch up to what we already know. Yes! It works in humans!

[plantrader]

@wild, I don't recall commenting on your writing style and I don't care if you "love your shares". What is this, a school yard? But it's a fact that, according to many here, something big is always just about to happen. For years. I really enjoy some of the info you dig up. If it makes you or anyone else feel better to be vocal about something amazing being perpetually right

[N0taP00p]

@wildbird: You missed the point, as usual. If 3 years ago, TLT didn't have all these things, why were you still saying BTD is right around the corner, no more money needed, we should expect a buyout or JV? So the ask was, switch gears to posting useful links. Some of us have been holding longer than you.. I have half a mind to put you on ignore. 

[3Crows]

@ NOtaPOOp: I have been here only a few short months.  In that time, after having established a healthy position in TLT, I have read every post on this board. It did not take me long to discriminate who were the legitimate, intelligent, thought-provoking, informed, and respectful posters from those who were not. If one wants their voice heard, decorum and courtesy go a long way. (Having said

[skys1]

Gee, I wonder why wildbird has a rep of over 1,000 while Poop & plantrader are both under 300.

[plantrader]

@skys, I try to recognize positives as well as concerns or uncertainties. What about you? If I had a dollar for every one of your time-based price predictions, I'd still have nothing. I think TLT has very exciting potential and sure hope it pans out. I'll leave it at that.

[N0taP00p]

@3crows: Thanks. Just check your spelling though.  Enjoy those thought provoking posts.

[Legit62]

N0taP00p, as much as i dont agree with your posts, free speech is ok with me even though down here in US they are trying to remove it, its great to agree to disagree, hoping we hit it soon, will be a very rich man, everyone has an opinion and love it

[N0taP00p]

@Legit:  Thanks.  I appreciate that view.  We don't have to agree on everything. I just try to remind  people who have been saying "anytime now!" for literally donkeys years that it's ok to celebrate every delay and dilution within your own mental construct of successful execution, but it's also good to respect an investor's healthy skepticism. 

[3Crows]

Sorry, Poopster, I'm bilingual and often make spelling errors. Please feel free to correct me. I always appreciate the help.