Theralase Technologies Inc. V.TLT

Anticancer Activity of Metallodrugs

[Oden6570]

7.2.3. Polypyridyl Ru(II) Complexes as Photosensitisers (PS) in Photodynamic Therapy (PDT) Polypyridyl-type Ru(II) complexes, whether coordination complexes or organometallic complexes, have properties that make them suitable for use in PDT applications. Photodynamic therapy is a therapeutic technique approved for the treatment of cancer that aims to exert its action in a localised manner while reducing side effects. The basis of this therapy is based on the use of a molecule capable of being activated by light, called photosensitiser visible light and molecular oxygen [183]. Photodynamic therapy consists of two steps: first, the PS is administered so that it accumulates in the cancerous tissues and, in the second step, it is exposed to light. These two independent steps reduce side effects because the photosensitiser, which is non-toxic in the dark, is only activated when irradiated with light that is concentrated on the specific area where the tumour is located, destroying it. This is a Int. J. Mol. Sci. 2024, 25, 7314 27 of 45 way of reducing side effects as the PS only acts on the irradiated area and not on healthy tissue [184]. Some polypyridyl-type Ru(II) complexes may act as agents for teragnosis, as they can exert a therapeutic function, act as a photosensitiser of PDT, and as a bioimaging agent for diagnosis [185]. The TLD-1433 complex, described by S. McFarland’s research group, 2020, is the first Ru(II)-based photosensitiser for photodynamic therapy to enter human clinical trials for the treatment of muscle-invasive bladder cancer
Anticancer-Curieses_et_al-2024-IJMS.pdf

[Tarbaby]

Good analysis.. But you did not mention that the NEW PDT is Xray PDT. The xrays turn into photons deep in a body to trigger the drug to kill cancer....Its a New ball game...huge future coming. Check out Fox Chase clinical trial using xrays for PDT. Munster University in Germany has an xray Pdt trial going also. Plus a few others. But none have Rutherrin...we do.

[stocksnbonds458]

Xrays ARE photons, they are high energy photons (or high frequency light waves if you like).They dont "turn" into photons. They may certainly lose energy as they pass through tissue though, and in doing so be reduced to microwaves or some other lower energy/lower frequency component of the light spectrum

[Tarbaby]

I believe the xray photons have some interactions in the body that creates  blue wavelength light. That may be what triggers the Rutherrin to create radical oxygen molecules which destroy the cancer cells. It isn t the xrays themselves destroying the csncer although they may help to weaken it. I believe they just use short bursts of xrays not continuous radiation.