Theralase Technologies Inc. V.TLT

POTENTIAL HOME CANCER TREATMENT

[Tarbaby]

Roger states that...pending GLP toxicology studies of Rutherrin and regulatory approval... they plan to start these trials.
Does this mean that toxicology of Rutherrin instilled by iv  has not yet been proven safe..?

[Dumbeldorfwhite]

No been saying that for literally years, but again everyone here just turns a blind eye. They can't do human trials without it, and they have been saying pending GLP toxicology for probably 2-3 years now. Just more Petri dish fluff. Clearly the market doesn't care much.

[Tarbaby]

THIS IS VITAL ...1 Can Rutherrin safely  be taken by mouth or by IV...or  2. can it be instilled into the colon for colorectal cancer treatment which is a huge potential market. Or 3. Can it be injected directly into a solid tumour ? Or are toxicology studies still pending on these questions.?

[menoalittle]

Just think for a minute or two about the implications (and potential) of this alone: It's been proven that it can (very safely) be instilled into the bladder. The colon is very safely prepped (cleaned) for a colonoscopy. Proceed with an enema using a prescribed about of Rutherrin. Hold as long as possible for maximum absorption of Rutherrin. Take the prescribed dose of

[Dumbeldorfwhite]

That's factually not correct TLD1433 and Rutherrin are different drugs buddy

[DJDawg]

That is always the wording. It is safe but you have to do a lot of work on the animal models to figure out dosing and then extrapolate to humans. One background hope that I have is the mostly quiet Dr. Mandel. I've read his papers and he is first rate researcher. He would not be involved in the day to day of clinical trials so I would hope he has been doing good labwork on an ongoing basis

[Tarbaby]

Thanks DJDAWG..you state.. it is safe.. Do you mean that toxicology has been done? I dont see that statement on their website. Roger MUST clarify this. Once he does the stock price will surely jump.

[DJDawg]

What I mean is that they have produced lots of animal data and no reported adverse effects that would preclude human trials.

[Tarbaby]

Thanks again for your info but the company MUST clarify the toxicology matter before I will buy more stock. Others likely feel the same. Once they get regulatory approval..Wow...rocket time.!

[menoalittle]

Hey tarbaby... Try giving a little bit of thought for a few minutes to that last post of mine.

[Tarbaby]

Thanks Meno..Agreed the HUGE  potential might be there for treating colon cancer. Its number 2 in cancer deaths... But the colon absorbs unlike the bladder. So safety in the bladder might not assure safety in the colon. Unless toxicology is proven safe for human use. Lets go Roger..

[Dumbeldorfwhite]

It's not idk how many times I can say it. No it is not proven safe for humans, TLD 1433 was not rutherrin

[DJDawg]

Proven safe is a tricky wording. Yes. DDFW is correct has not proven safe in humans. All data provided to date suggests that it is safe in animal models that are used as a proxy. The process involves giving the drug to animals and measuring a million parameters to see if any suggestion of "toxicity". They have been doing this for a while and so far all reports are good but it is not

[Tarbaby]

Thanks DJ..that clarifies things a lot. But why dont they try it instilled inside a colon. Or maybe they have. If it worked there then colon cancer and bladder cancer cover a huge need..and worth billions and big benefit to society..

[Galaxym31]

Cancer is not safe for any mammals .

[CancerSlayer]

Rutherrin & TLD 1433 are practically twins from a biological safety profile imo.  Keep in mind, Ruthenium/TLD 1433 closely mimics its relative, iron.  This enables it to have a high "affinity for transferrin" (a natural transporter of iron in the body), which is one of the core reasons for its low in vivo toxicity... as evidenced thus far in our current NMIBC study.  

[wildbird1]

Excellent post CancerSlayer... To complement your post..In the Feb23,2015 PressRelease...  2015-02-23 | Theralase Identifies Potential Mechanism of How Lead Anti-Cancer Drug Works to Destroy Cancer and Discovers New Application to Detect Cancer Cells | TSXV:TLT | Press Release TLT said'' Rutherrin is able to provide 300% more payload of TLD-1433 to the cancer cell than TLD-1433

[menoalittle]

Don't forget to keep colon cancer near the top of that future big revenue maker list.  It has astonishingly huge potential not only for cancer treatment, but given Rutherrin's highly likely safety profile and ease of use (and activation with Metformin,) perhaps also a nice revenue stream for colon cancer prevention after a few "suspicious" polyp are removed in a routine

[CancerSlayer]

Nice post wildbird1... And imagine the potential veterinary applications.  There are almost as many pet owners/lovers as there are people...And perhaps animal model testing in rats will be more translatable to dogs, making both dog owners & PETA folks happy ; ).

[Johnandrose22]

10 years ago this company caught my interest, imagination and enthusiasm with the introduction of TLD 1433 and its extraordinary promise. Now, with the company's recent NR, my feelings are renewed with the possibilities of Rutherin and its applications. In the spirit of imagination, just a question to the board. Given the apparent MOA of Rutherin/ Metformin,  Could the company run a