ARCA biopharma, Inc. (Nasdaq: ABIO), a biopharmaceutical company
developing genetically-targeted therapies for cardiovascular diseases,
today announced that a joint Laboratory Corporation of America®
Holdings (LabCorp®) (NYSE:LH) and ARCA personalized medicine
abstract has been accepted for moderated poster presentation at the 18th
Annual Scientific Meeting of the Heart Failure Society of America, being
held September 14-17, 2014 in Las Vegas, Nevada. The poster describes
the genetic test that is being used to select patients for GENETIC-AF, a
Phase 2B/3 adaptive design clinical trial. The GENETIC-AF trial will
evaluate Gencaro™ (bucindolol hydrochloride) as a potential treatment
for the prevention of atrial fibrillation (AF) in patients with heart
failure and left ventricular dysfunction who also have a specific
genotype of the beta-1 adrenergic receptor (389 arginine homozygous),
which ARCA believes is present in approximately 50% of the U.S.
population. LabCorp is performing the genetic testing for the GENETIC-AF
trial.
Melissa Barhoover, Ph.D., IVD Regulatory Manager at LabCorp Clinical
Trials, and Christopher Dufton, Ph.D., Vice President, Clinical
Development at ARCA, are scheduled to present “Personalized Medicine:
Prospective Patient Selection Utilizing an ADRB1 Genotype Assay in the
GENETIC-AF Clinical Trial” during the poster session Monday, September
15, 2014, 5:15 – 6:15 pm PT.
More information about the conference is available at: http://www.hfsa.org/annual_meeting.asp.
About ARCA biopharma
ARCA is dedicated to developing genetically-targeted therapies for
cardiovascular diseases. The Company's lead product candidate, Gencaro™
(bucindolol hydrochloride), is an investigational, pharmacologically
unique beta-blocker and mild vasodilator being evaluated for atrial
fibrillation in the Phase 2B/3 clinical trial GENETIC-AF, which began
enrolling patients in the second quarter of 2014. ARCA has identified
common genetic variations that it believes predict individual patient
response to Gencaro, giving it the potential to be the first
genetically-targeted atrial fibrillation prevention treatment. ARCA has
a collaboration with Medtronic, Inc. for support of the GENETIC-AF
trial. For more information please visit www.arcabiopharma.com.
Safe Harbor Statement
This press release and the anticipated poster presentation contain
"forward-looking statements" for purposes of the safe harbor provided by
the Private Securities Litigation Reform Act of 1995. These statements
include, but are not limited to, statements regarding, potential timing
for patient enrollment in the GENETIC-AF trial, the sufficiency of the
Company’s capital to support its operations, the potential for genetic
variations to predict individual patient response to Gencaro, Gencaro’s
potential to treat atrial fibrillation, future treatment options for
patients with atrial fibrillation, and the potential for Gencaro to be
the first genetically-targeted atrial fibrillation prevention treatment.
Such statements are based on management's current expectations and
involve risks and uncertainties. Actual results and performance could
differ materially from those projected in the forward-looking statements
as a result of many factors, including, without limitation, the risks
and uncertainties associated with: the Company's financial resources and
whether they will be sufficient to meet the Company's business
objectives and operational requirements; results of earlier clinical
trials may not be confirmed in future trials, the protection and market
exclusivity provided by the Company’s intellectual property; risks
related to the drug discovery and the regulatory approval process; and,
the impact of competitive products and technological changes. These and
other factors are identified and described in more detail in ARCA’s
filings with the SEC, including without limitation the Company’s annual
report on Form 10-K for the year ended December 31, 2013, and subsequent
filings. The Company disclaims any intent or obligation to update these
forward-looking statements.
Copyright Business Wire 2014