Provectus Biopharmaceuticals Announces Abstract Available on PV-10 Plus Radiotherapy in Melanoma
Abstract Published in Conjunction with 2016 ASCO Annual Meeting
ASCO Meeting Runs June 3-7, 2016, Chicago, Illinois
Provectus Biopharmaceuticals, Inc. (NYSE MKT:PVCT, www.provectusbio.com), a clinical-stage oncology and dermatology biopharmaceutical company ("Provectus" or “The
Company”), today announced the availability of an abstract titled “A phase 2 study of intralesional PV-10 followed by radiotherapy
for localized in transit or recurrent metastatic melanoma” that has been published in conjunction with the annual meeting of the
American Society of Clinical Oncology ("ASCO") being held in Chicago June 3-7, 2016.
To see this abstract, visit: http://abstracts.asco.org/176/AbstView_176_167555.html
The abstract, ID: e21072, was published May 18, 2016, and is authored by Matthew Foote and colleagues at the Princess Alexandra
Hospital and University of Queensland, in Brisbane, Australia.
Eric Wachter, Ph.D., Chief Technology Officer of Provectus, noted, “This abstract describes initial analysis of data from an
investigator-initiated study of PV-10 followed by regional radiotherapy for refractory melanoma. Patients received a single course
of PV-10, and if not immediately achieving a complete response they received a modest dose of radiation 6-10 weeks later. This
combination yielded an 87% response rate with a third of patients achieving complete response. The response was durable (12.2
months mean duration of complete response), however, the protocol did not allow for subsequent retreatment, and the authors report
that 80% of patients eventually had recurrence. Nonetheless, the melanoma specific survival of almost 5 and a half years is
encouraging, and I agree with the authors’ conclusion that these results justify expanded evaluation in a randomized trial.”
Wachter continued, “This work arose from observations by these same researchers several years ago that, as they stated at the
time, melanoma patients treated with PV-10 followed by external beam radiotherapy ‘had an impressive response.’ Also as observed in
those early cases, the data reported in this ASCO abstract show that there appears to be minimal potential for increased side
effects when PV-10 is used in combination with radiotherapy.”
Wachter concluded, “The primary purpose of presenting research data at international meetings such as ASCO is to share knowledge
within the medical community. An important implication of this is fostering dialog within the community regarding appropriate use
of such data. In this case, I hope this initial report will help foster relationships that facilitate advancement of these findings
into advanced studies, as suggested by the authors.”
About ASCO
ASCO promotes and provides for lifelong learning for oncology professionals; cancer research; an improved environment for
oncology practice; access to quality cancer care; a global network of oncology expertise; and educated and informed patients with
cancer. ASCO is supported by its affiliate organization, the Conquer Cancer Foundation, which funds groundbreaking research and
programs that make a tangible difference in the lives of people with cancer. For further information, visit http://www.asco.org/
About Provectus Biopharmaceuticals, Inc.
Provectus Biopharmaceuticals, Inc., specializes in developing oncology and dermatology therapies. PV-10 is a novel
investigational drug for cancer: melanoma, breast cancer and cancers of the liver. The Company has received orphan drug
designations from the FDA for its melanoma and hepatocellular carcinoma indications. PH-10, its topical investigational drug for
dermatology, is undergoing clinical testing for psoriasis and atopic dermatitis. Provectus has completed Phase 2 trials of PV-10 as
a therapy for metastatic melanoma, and of PH-10 as a topical treatment for atopic dermatitis and psoriasis. Information about these
and the Company's other clinical trials can be found at the NIH registry, www.clinicaltrials.gov. For additional information about Provectus, please visit the Company's website at
www.provectusbio.com or contact Porter, LeVay & Rose, Inc.
FORWARD-LOOKING STATEMENTS: This release contains "forward-looking statements" as defined under U.S. federal securities laws.
These statements reflect management's current knowledge, assumptions, beliefs, estimates, and expectations and express management's
current views of future performance, results, and trends and may be identified by their use of terms such as "anticipate,"
"believe," "could," "estimate," "expect," "intend," "may," "plan," "predict," "project," "will," and other similar terms.
Forward-looking statements are subject to a number of risks and uncertainties that could cause our actual results to materially
differ from those described in the forward-looking statements. Readers should not place undue reliance on forward-looking
statements. Such statements are made as of the date hereof, and we undertake no obligation to update such statements after this
date.
Risks and uncertainties that could cause our actual results to materially differ from those described in forward-looking
statements include those discussed in our filings with the Securities and Exchange Commission (including those described in Item 1A
of our Annual Report on Form 10-K for the year ended December 31, 2015) and the following:
- our determination, based on guidance from the FDA, whether to proceed with or without a partner with
the fully enrolled phase 3 trial of PV-10 to treat locally advanced cutaneous melanoma and the costs associated with such a trial
if it is necessary to complete (versus interim data alone);
- our determination whether to license PV-10, our investigational drug product for melanoma and other
solid tumors such as cancers of the liver, if such licensure is appropriate considering the timing and structure of such a
license, or to commercialize PV-10 on our own to treat melanoma and other solid tumors such as cancers of the liver;
- our ability to license PH-10, our investigational drug product for dermatology, on the basis of our
phase 2 atopic dermatitis and psoriasis results, which are in the process of being further developed in conjunction with
mechanism of action studies; and
- our ability to raise additional capital if we determine to commercialize PV-10 and/or PH-10 on our
own, although our expectation is to be acquired by a prospective pharmaceutical or biotech concern prior to
commercialization.
Provectus Biopharmaceuticals, Inc.
Peter R. Culpepper, Interim CEO, COO
Phone: 866-594-5999 #30
or
Porter, LeVay & Rose, Inc.
Marlon Nurse, DM, SVP – Investor Relations
Phone: 212-564-4700
or
Allison + Partners
Todd Aydelotte, Managing Director – Media Relations
Phone: 646-428-0644
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