BOSTON, June 2, 2016 /PRNewswire/ -- Exercise-associated
muscle cramps are agonizing. Millions of athletes and fitness enthusiasts suffer from them – even the best trained and most
nutritionally-savvy. They're painful, unpredictable and can rob an athlete of a killer performance and confidence. Existing
"remedies" that target the muscle have limited scientific evidence that they work.
Breakthrough research, to be presented today at the American College of Sports Medicine's Annual Meeting and published in the
Journal of the American Medical Athletic Association later this month, has led to the development of a revolutionary new sports
shot, HOTSHOT™, that is scientifically proven to prevent
and treat muscle cramps by stopping them where they start: at the nerve.
Invented by a Nobel Prize-winning neuroscientist and endurance athlete in collaboration with a Harvard
Medical School neurobiology professor, HOTSHOT, previously codenamed #ITSTHENERVE, is a 1.7 fluid ounce sports shot
comprised of a proprietary formula of GMO-free organic ingredients with a kick. Consumed before, during or after exercise,
HOTSHOT facilitates the synchronization of communication between the nerve and muscle thereby giving athletes greater control
over the way their nerves and muscles work together, boosting their Neuro Muscular Performance (NMP) to prevent and treat muscle
cramps. Now athletes can push harder, train longer and finish stronger.
How Curiosity Killed the Cramp: Invention Inspired by Experience
Rod MacKinnon, MD, a Nobel Prize-winning neuroscientist, along with close friend and
colleague Bruce Bean, PhD, a neurobiology professor at Harvard Medical
School, sought to find a cure for cramping after a life-threatening event occurred off the coast of Cape Cod in 2010. The pair was enjoying a long-distance sea kayaking trip when almost simultaneously their
arms seized up miles from shore, in dangerous conditions. Both were surprised by the muscle cramps because they had taken
precautions to stay well-hydrated and topped up on electrolytes.
Curious as to what was known about the cause and cure of muscle cramps, MacKinnon and Bean dug into the literature and
realized that cramping is not caused by dehydration or electrolyte imbalance, but instead originates from hyper-excited
motor-nerves in the spinal cord.
Building off MacKinnon's Nobel Prize-winning research on ion channels, they hypothesized that activating certain Transient
Receptor Potential (TRP) ion channels in sensory nerves in the mouth, throat and esophagus could send signals to calm those
hyper-excited motor neurons, thereby stopping muscle cramps before they start.
Over several years, they experimented with numerous natural ingredients that activate certain TRP ion channels and refined the
proprietary formula of ingredients found in HOTSHOT – now scientifically proven to prevent and treat muscle cramps.
Neuro Muscular Performance: A New Category in Sports Nutrition
In their pursuit to find a solution for muscle cramps, MacKinnon and Bean accidentally unlocked the power of Neuro
Muscular Performance – the way that an athlete's nerves and muscles work together in an optimal way. New evidence shows that
boosting Neuro Muscular Performance also reduces post-exercise muscle soreness. The exercise-associated muscle cramp study of
HOTSHOT conducted by Penn State University showed a statistically significant reduction in muscle
soreness during the first 20 minutes after a muscle cramp, compared to placebo. And in field studies among athletes using
HOTSHOT prior to working out, the majority reported reduced post-exercise soreness.
"This is a brand new concept in sports nutrition: how to stimulate sensory nerves as a way to affect your muscle function,"
said MacKinnon. "This is cool science. The breakthrough and what we now know is how to prevent and treat muscle cramps.
However, what intrigues me is what I'm hearing from athletes about other potential benefits. This is only the
beginning."
The company's scientists, in partnership with leading sports science institutions, are continuing to study how HOTSHOT affects
boosting an athlete's Neuro Muscular Performance and how that may translate to additional benefits for athletes.
Supported by Science
HOTSHOT's formula of strong TRP activators has shown a statistically significant reduction in muscle cramp intensity
compared to placebo in two distinct muscle cramp models: 1) electrically induced muscle cramps; and 2) an innovative new model
developed by Penn State University in which healthy volunteers maximally contracted one calf muscle
until cramping occurred.
A field study of healthy, cramp-prone athletes who consumed HOTSHOT 15-30 minutes before their normal training sessions showed
a 50 percent or more reduction in the frequency of exercise-associated muscle cramps compared to the observed baseline frequency.
In addition, the athletes reported a quicker return to training when a cramp episode did occur.
"I am not aware of any other consumer product that has demonstrated significant efficacy in mitigating muscle cramps in such a
rigorous double-blind scientific study," said Larry Kenney, Ph.D., FACSM, Marie Underhill Noll
Chair in Human Performance and Professor of Physiology and Kinesiology at Penn State University.
Trusted by World-Class Athletes: TeamHOTSHOT
The proprietary HOTSHOT formulation is NSF Certified for Sport® and has been extensively tested by amateur and
world-class athletes across endurance sports, track and field, professional football and tennis. Among the elite athletes and
sports scientists, who are the company's brand ambassadors and rely on the product's NMP benefits, are:
- U.S. National Team distance runners expected to compete on the world stage this summer, Shalane Flanagan, Amy Cragg, Colleen Quigley
and Evan Jager.
- Five-time IRONMAN® and IRONMAN 70.3® World Champion, Craig 'Crowie' Alexander.
- Neurosurgical Consultant to the Denver Broncos, Dr. Chad Prusmack.
"I have been an endurance athlete for over 20 years," said Craig 'Crowie' Alexander, 5-time IRONMAN and IRONMAN 70.3 World
Champion. "Muscle cramps are a source of concern for me because they put a brake on your momentum. They can strike at the
beginning of the race or when you are meters from the finish line. A cramp can paralyze you mentally, and physically, and cost
you crucial time. So HOTSHOT is a big confidence-builder and game changer in endurance sports, knowing you won't be stopped
in your tracks by cramping."
Boost Your Neuro Muscular Performance
HOTSHOT is available online at www.TeamHOTSHOT.com and at
select specialty retailers in Los Angeles, Calif., Boulder,
Colo. and Boston, Mass. A single serve bottle is $7
USD, while six-bottle and 12-bottle packs are $35 and $65 USD,
respectively.
To learn more about HOTSHOT and the science around Neuro Muscular Performance, visit www.TeamHOTSHOT.com. Join the conversation on Facebook, Twitter and Instagram.
About HOTSHOT
Invented by Rod MacKinnon, a Nobel Prize-winning neuroscientist and endurance athlete,
HOTSHOT™ is the sports shot with a kick that is scientifically proven to prevent and treat muscle cramps. A scientific
breakthrough in sports nutrition, HOTSHOT is a kick-ass proprietary formulation of organic ingredients that boosts Neuro Muscular
Performance – how an athlete's nerves and muscles work together in an optimal way. MacKinnon and Harvard neurobiology professor Bruce Bean spent several years calibrating this
precise formulation of Transient Receptor Potential (TRP) activator ingredients that stimulate TRP ion channels in the mouth,
esophagus and stomach that directly influence and regulate nerve function. Translation? HOTSHOT stops muscle cramps where they
start – at the nerve – allowing athletes to push harder, train longer and finish stronger. HOTSHOT is a non-GMO Project Verified,
USDA Certified Organic product that is NSF Certified for Sport®. To learn more, visit www.TeamHOTSHOT.com. HOTSHOT is a product of Flex Innovation Group LLC, a division of Flex Pharma, Inc. (Nasdaq
FLKS).
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