Bristol-Myers Squibb Company (NYSE: BMY)
and The University of Texas MD Anderson Cancer Center revealed Tuesday a new clinical research alliance to assess innovative
tactics for the potential use of Bristol-Myers Squibb's immuno-oncology (I-O) agents Opdivo (nivolumab) and Yervoy (ipilimumab) to
treat early- and advanced-stage lung cancer patients.
Bristol-Myers said the alliance would help support multiple Phase 1 and 2 clinical studies testing Opdivo as monotherapy, in
combination with Yervoy, or in regimens with other agents, radiation or surgery in a range of clinical settings. The company added
that these trials would also add extensive translational work including exploration of novel biomarkers to better differentiate
responders from non-responders in lung cancer and preclinical studies of next generation immunotherapeutic agents, which may be
used to expand the benefits to larger numbers of patients.
The company's MD, Global Clinical Research Lead, Oncology, Jean Viallet, said, "Strategic collaborations with academia have been
central to helping Bristol-Myers Squibb develop and deliver new immuno-oncology treatment options to patients. This collaboration
will leverage the considerable experience of MD Anderson to accelerate and expand our scientific and clinical understanding of how
the immune system and other treatments might work together to fight cancer."
Similarly, Head and Neck Medical Oncology at MD Anderson, John Heymach, also reacted to say, "Immunotherapy agents, such as
nivolumab, already have prolonged the lives of many patients with metastatic NSCLC. Through our multidisciplinary collaboration
with Bristol-Myers Squibb, we look forward to exploring innovative ways to integrate immunotherapy with other treatments, including
surgery and radiation, with the goal of improving standard of care and expanding treatment options for all patients, including
those with early stage disease."
The said that in September 2014, both reached an an I-O clinical collaboration with a focus on the assessment of Bristol-Myers
Squibb I-O assets for the treatment of hematologic malignancies, like acute and chronic leukemia. Similarly, in December lastyear,
Bristol-Myers Squibb and MD Anderson have signed a collaboration deal to leverage MD Anderson's immunotherapy platform to help to
link immunologic data with the genomic and proteomic platforms across a range of cancer types.
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