Sickle Cell Partnership Creates Demonstration Project to Treat Children in Angola
The Angola Sickle Cell Initiative, a public-private partnership of the Angola Ministry of Health, the Baylor College of Medicine
International Pediatric AIDS Initiative (BIPAI), Texas Children’s Hospital and Chevron, is teaming up with the global
biopharmaceutical company Bristol-Myers Squibb to provide children with sickle cell disease in Angola with an effective medication to
which many patients in the country have lacked access.
The program will provide thousands of Angolan children regular access to Droxia (hydroxyurea), which is indicated to
reduce the frequency of painful crises and the need for blood transfusions in patients with sickle cell anemia with recurrent
moderate to severe painful crises. This new five-year demonstration program is intended to build understanding of the effectiveness
of treating children in resource-limited settings and to establish the cost benefits to the healthcare systems.
“World Sickle Cell Day was June 19, so this is a momentous time to announce this new partnership to provide potentially
life-altering medication to thousands of children in Angola, one of Africa’s countries hardest hit by sickle cell disease,” said
Dr. David Poplack, director of the Texas Children’s Cancer and Hematology Centers and professor of pediatric oncology at Baylor
College of Medicine. “Hydroxyurea is known to lessen the devastating complications of sickle cell disease.”
Sickle cell disease is an inherited disorder in which red blood cells become irregularly shaped. These sickle-shaped cells can
get stuck in small blood vessels, which can slow or block blood flow and oxygen to parts of the body, resulting in painful
episodes, serious infections, chronic anemia, damage to body organs and stroke, among other complications.
Angola has one of the world's highest rates of the genetic blood condition with up to 10,000 babies born with the disease each
year. By some estimates, up to 50 percent of these children die before five years of age. However, most patients in the country
have not had access to hydroxyurea.
Bristol-Myers Squibb will donate Droxia for the treatment of up to 1,200 children during the first two years of the
program, increasing this up to 4,100 after the pilot period. The program will launch in Luanda and Cabinda and later will expand to
additional sites. Last year, Bristol-Myers Squibb made an initial donation of Droxia to the Angola Sickle Cell
Initiative.
“We are proud to partner with the Angola Sickle Cell Initiative to help bring much needed treatment to infants born with this
painful and deadly disease,” said John Damonti, vice president of corporate philanthropy at Bristol-Myers Squibb and president of
the Bristol-Myers Squibb Foundation. “As important as providing treatment to the 4,100 children is that at the end of this
five-year demonstration project, we should have ample data needed for governments and funders to consider providing the resources
necessary to support large-scale treatment programs.”
According to Bristol-Myers Squibb, hydroxyurea is indicated to reduce the frequency of painful crises and need for blood
transfusions in adult patients with sickle cell anemia with recurrent moderate to severe painful crises (generally at least 3
during the preceding 12 months). Hydroxyurea should be administered under the supervision of a physician experienced in the use of
this medication for the treatment of sickle cell anemia since treatment of patients with hydroxyurea may be complicated by severe,
sometimes life-threatening, adverse effects.
The Angola Sickle Cell Initiative will provide medical care and management of the drug to children in the treatment program. The
Angolan Ministry of Health has committed to the continued treatment of all the children on hydroxyurea when they reach 10 years
old. The emergency response and global health organization AmeriCares also is a key partner, shipping the drug from Bristol-Myers
Squibb to Angola.
Leaders of this new initiative hope to demonstrate over the five years the health benefits and cost effectiveness of a
hydroxyurea treatment program for infants with sickle cell disease, and use patient data and outcomes as the foundation for an
advocacy plan to provide treatment to all children in Angola and throughout the continent. Hydroxyurea currently has generic status
and is on the World Health Organization List of Essential Medicines.
“Agreements like this public-private partnership allow governments to address gaps in healthcare to meet the needs of its most
vulnerable citizens – sick children,” said Michael Mizwa, chief operating officer of BIPAI, and director of Texas Children’s Global
Health. “We hope BIPAI’s legal and operational framework in Angola will provide a foundation for many more such partnerships in the
future.”
The Angola Sickle Cell Initiative has been in place in Angola since 2011. Before its launch, newborns were not screened for the
disease. Since 2011, more than 150,000 babies have been screened and more than 1,700 babies and children are now in care and
treatment.
Led by Dr. Gladstone Airewele, associate professor of pediatrics at Baylor and head of the Global Hematology Program at Texas
Children’s Hospital, the Initiative also includes an education and training component. More than 1,500 Angolans have been trained
through the program, including local physicians, nurses, laboratory technicians, phlebotomists, social workers and research
coordinators.
The Baylor International Pediatric AIDS Initiative at Texas Children’s Hospital, or BIPAI, is the foundation on which the Angola
Sickle Cell Initiative is based. BIPAI treats more than 250,000 children with HIV/AIDS across a network of clinical centers in
Africa and Romania in which the Bristol-Myers Squibb Foundation is also a major partner.
Texas Children’s Cancer and Hematology Centers have provided key support in the success of the Angola Sickle Cell Initiative,
and Chevron has provided $9 million in funding over nine years to the Angola Sickle Cell Initiative.
About Bristol-Myers Squibb
Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative
medicines that help patients prevail over serious diseases. For more information about Bristol-Myers Squibb, visit us at BMS.com or follow us on LinkedIn, Twitter, YouTube and Facebook.
About AmeriCares
AmeriCares is an emergency response and global health organization committed to saving lives and building healthier futures for
people in crisis in the United States and around the world. Every day, AmeriCares puts critically needed medicines and supplies in
the hands of frontline health workers and develops innovative, sustainable health improvements in their communities. For more
information, visit americares.org.
Baylor College of Medicine
Dana Benson, (713) 798-4710
benson@bcm.edu
www.bcm.edu.news
or
Dipali Pathak, (713) 798-4710
pathak@bcm.edu
or
Bristol-Myers Squibb
Lisa McCormick Lavery, (609) 252-7602
lisa.mccormicklavery@bms.com
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