BERKELEY, Calif., Nov. 09, 2016 (GLOBE NEWSWIRE) -- Aduro Biotech, Inc. (Nasdaq:ADRO), a biopharmaceutical company
with three distinct immunotherapy technologies, announced that Tom Dubensky Jr., Ph.D., chief scientific officer of Aduro,
presented today about the company’s personalized LADD technology at the Society for Immunotherapy of Cancer (SITC) distinct session
titled New Cancer Immunotherapy Agents in Development being held in conjunction with the SITC annual meeting.
LADD is Aduro's proprietary platform of live, attenuated double-deleted Listeria monocytogenes strains that have been engineered
to express tumor-associated antigens to induce an innate immune response and tumor-specific T cell-mediated immunity.
Personalized LADD, or pLADD, is a second generation LADD technology that is being designed for individualized, patient-specific
immunotherapy. The pLADD approach leverages the immune activating activity of the Listeria bacterial vector in combination
with neoantigens, or the tumor markers specific to an individual’s cancer, which are derived from the patient’s own unique tumor
cells. Once administered, pLADD therapies are expected to mobilize the immune system through first an immediate recognition of the
presence of Listeria as being foreign and then second a specific and customized immune attack on cells containing the tumor
neoantigens presented by pLADD. An Investigational New Drug (IND) application has been accepted, and a Phase 1 trial
evaluating the safety and immunogenicity of pLADD in patients with advanced gastro-intestinal cancers is planned.
“There is tremendous excitement in the oncology field to develop personalized therapies as the next new wave in immunotherapy to
specifically customize treatment for each patient based on neoantigens that are unique to a patient’s tumor,” said Tom Dubensky
Jr., Ph.D., chief scientific officer of Aduro. “We are excited about the potential of our pLADD program, which has been shown to
induce anti-tumor immune responses specific to tumor neoantigens and correlate with longer survival in preclinical models.
Additionally, in these models, we observed a synergistic anti-tumor effect when pLADD was combined with an anti-PD-1 antibody,
resulting in a significant reduction in tumor volume and increased survival.”
The pLADD technology platform is well-suited to maximize the potential benefit of personalized therapy through the ability to
engineer the therapy with multiple tumor-specific neoantigens, as well as to leverage an efficient small-scale manufacturing
process in its production.
To create a patient-specific pLADD therapy, a physician begins by removing tumor cells from the patient. These cells are
analyzed in order to molecularly characterize (sequence) the tumor, including any mutations that are unique to the patient’s own
tumor cells. Predictive algorithms for antigen processing are run to identify pertinent tumor antigens. Aduro then creates a LADD
strain that includes the patient-specific neoantigens for administration.
Preclinical Data with pLADD
Preclinical data showed that pLADD induced a robust immune response, including broad innate immune responses involving cytokines,
chemokines, natural killer, and gamma delta T cells, as well as antigen-specific adaptive T cell responses (CD8+ and CD4+).
In preclinical models, pLADD remodeled the tumor microenvironment, whereby an increase in infiltration of neutrophils, T cells and
dendritic cells was observed. The combination of pLADD with an anti-PD-1 led to a sustained immune response and significant
prolongation of survival in these models.
Detailed preclinical data will be presented by Aduro scientist Meredith Leong, Ph.D., on Saturday, November 12, 2016 at the SITC
Annual Meeting (Poster #366).
About Aduro
Aduro Biotech, Inc. is an immunotherapy company focused on the discovery, development and commercialization of
therapies that transform the treatment of challenging diseases. Aduro's technology platforms, which are designed to harness the
body's natural immune system, are being investigated in cancer indications and have the potential to expand into autoimmune and
infectious diseases. Aduro's LADD technology platform is based on proprietary attenuated strains of Listeria that have been
engineered to express tumor-associated antigens to induce specific and targeted immune responses. This platform is being developed
as a treatment for multiple indications, including pancreatic, ovarian, lung and prostate cancers, mesothelioma and glioblastoma.
Additionally, a personalized form of LADD, or pLADD, is being developed utilizing tumor neoantigens that are specific to an
individual patient’s tumor. Aduro's STING Pathway Activator platform is designed to activate the intracellular STING receptor,
resulting in a potent tumor-specific immune response. ADU-S100 is the first STING Pathway Activator compound to enter the clinic
and is currently being evaluated in a Phase 1 study in patients with cutaneously accessible metastatic solid tumors or lymphomas.
Aduro’s B-select monoclonal antibody platform includes a number of immune modulating assets in research and preclinical
development. Aduro is collaborating with leading global pharmaceutical companies to expand its products and technology platforms.
For more information, please visit www.aduro.com.
Cautionary Note on Forward-Looking Statements
This press release contains forward-looking statements for purposes of the safe harbor provisions of the Private Securities
Litigation Reform Act of 1995. Forward-looking statements include statements regarding our intentions or current expectations
concerning, among other things, the potential for pLADD and our other technology platforms, plans, timing and the availability of
results of our clinical trials, our ability to resume new patient enrollment in LADD clinical trials and the potential for eventual
regulatory approval of our product candidates. In some cases, you can identify these statements by forward-looking words such as
“may,” “will,” “continue,” “anticipate,” “intend,” “could,” “project,” “expect” or the negative or plural of these words or similar
expressions. Forward-looking statements are not guarantees of future performance and are subject to risks and uncertainties
that could cause actual results and events to differ materially from those anticipated, including, but not limited to, our history
of net operating losses and uncertainty regarding our ability to achieve profitability, our ability to develop and commercialize
our product candidates, our ability to use and expand our technology platforms to build a pipeline of product candidates, our
ability to obtain and maintain regulatory approval of our product candidates, our inability to operate in a competitive industry
and compete successfully against competitors that have greater resources than we do, our reliance on third parties, and our ability
to obtain and adequately protect intellectual property rights for our product candidates. We discuss many of these risks in
greater detail under the heading “Risk Factors” contained in our quarterly report on Form 10-Q for the quarter
ended September 30, 2016, which is on file with the Securities and Exchange Commission. Any forward-looking
statements that we make in this press release speak only as of the date of this press release. We assume no obligation to update
our forward-looking statements whether as a result of new information, future events or otherwise, after the date of this press
release.
Contact: Sylvia Wheeler SVP, Corporate Affairs 510 809 9264 Media Contact: Susan Lehner 510 809 2137 press@aduro.com
