18 Biggest Mid-Day Gainers For Wednesday

• Orexigen Therapeutics, Inc. (NASDAQ: OREX) shares surged 44.3 percent to $2.99 after the company announced a new ad campaign that will launch this week called 'Brains Behind Weight Loss'.
• CymaBay Therapeutics Inc (NASDAQ: CBAY) shares climbed 33.7 percent to $2.54 after the company reported a licensing deal with Kowa Pharmaceuticals America, Inc. for exclusive US rights to arhalofenate.
• Evoke Pharma Inc (NASDAQ: EVOK) shares jumped 27 percent to $2.63. Evoke Pharma disclosed that Phase 3 Gimoti trial failed to reach its primary endpoint. However, the company announced that 51 percent of patients responded better to Gimoti than placebo.
• Merus NV (NASDAQ: MRUS) shares gained 22.9 percent to $25.90.
• PhotoMedex Inc (NASDAQ: PHMD) shares rose 22.1 percent to $2.97. PhotoMedex shares have increased 10.45 percent over the past 52 weeks, while the S&P 500 index has gained 12.18 percent in the same period.
• O2Micro International Limited (ADR) (NASDAQ: OIIM) shares surged 21.5 percent to $2.30 after the company revised its Q4 financial guidance. O2Micro raised its Q4 revenue guidance from $14.7 million-$15.6 million to $15.4 million-$15.9 million.
• Weight Watchers International, Inc. (NYSE: WTW) climbed 19.2 percent to $13.21.
• ImmunoGen, Inc. (NASDAQ: IMGN) shares rose 18 percent to $2.45 after gaining 1.96 percent on Tuesday.
• Shake Shack Inc (NYSE: SHAK) gained 7.7 percent to $38.90. Shake Shack will replace Chemours in the S&P SmallCap 600 after the close of trading on January 4.
• Partner Communications Company Ltd (ADR) (NASDAQ: PTNR) shares rose 6.8 percent to $5.43 after gaining 8.42 percent on Tuesday.
• Encana Corp (USA) (NYSE: ECA) shares rose 6.2 percent to $12.68 in pre-market trading. Ecana is expecting 2017 corporate margin to be greater than $10 per barrel of oil equivalent.
• Chemours Co (NYSE: CC) shares gained 6.2 percent to $22.53. Chemours will replace IDEXX Laboratories, Inc. (NASDAQ: IDXX) in the S&P MidCap 400 after the close of trading on January 4.
• Nivalis Therapeutics Inc (NASDAQ: NVLS) shares rose 5.2 percent to $2.32. Nivalis Therapeutics disclosed that it is exploring strategic alternatives for the company and has engaged Ladenburg Thalmann to act as an advisor.
• Abercrombie & Fitch Co. (NYSE: ANF) gained 5.1 percent to $12.73. FBR Capital upgraded Abercrombie & Fitch from Underperform to Market Perform.
• Fusion Telecommunications Int'l, Inc. (NASDAQ: FSNN) surged 4.7 percent to $1.52. Craig-Hallum initiated coverage on Fusion Telecommunications with a Buy rating.
• Global Blood Therapeutics Inc (NASDAQ: GBT) rose 4.2 percent to $14.90. JPMorgan initiated coverage on Global Blood Therapeutics with an Overweight rating.
• Achaogen Inc (NASDAQ: AKAO) rose 4.1 percent to $13.53. Leerink Swann initiated coverage on Achaogen with an Outperform rating.
• Aecom (NYSE: ACM) gained 3.4 percent to $38.26. Baird upgraded Aecom from Neutral to Outperform.

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