-- Fourth quarter 2017 EXONDYS 51 unaudited revenue of $57.3 million --
-- Full-year 2017 EXONDYS 51 unaudited revenue of $154.6 million --
-- Full-year 2018 EXONDYS 51 revenue guidance of $295 – $305 million --
-- 16 programs in development --
SAN FRANCISCO, Jan. 08, 2018 (GLOBE NEWSWIRE) -- Sarepta Therapeutics, Inc. (NASDAQ:SRPT), a commercial-stage
biopharmaceutical company focused on the discovery and development of precision genetic medicine to treat rare neuromuscular
diseases, today pre-announced its fourth quarter 2017 revenue and also provided full-year 2018 revenue guidance for EXONDYS 51
during the Company’s presentation at the 36th Annual J.P. Morgan Healthcare Conference. Sarepta’s president and chief
executive officer, Douglas Ingram, who presented on behalf of the Company, stated that revenue for the fourth quarter will total
$57.3 million and $154.6 million for the full-year of 2017. EXONDYS 51 revenue guidance for 2018 will be in the range of $295 –
$305 million.
“2017 was a remarkable year for Sarepta,” said Douglas Ingram, Sarepta’s president and chief executive officer.
“Our full-year 2017 revenue, representing one of the most successful rare disease launches in history, speaks to the value of
EXONDYS 51 and also to the ability of our talented colleagues at Sarepta to execute on our plans and deliver on our commitments.”
Mr. Ingram continued, “In 2017, we set the stage by successfully launching our first therapy, entering into
important collaborations and ensuring we have ample resources to invest in our impressive pipeline. In 2018, we are accelerating
our plans, moving 16 programs through various stages of development, and planning for multiple milestones and inflection
points. And we are doing all of this to serve our lofty but achievable aspiration: to improve and extend the lives of the
thousands of children suffering from DMD, expand our platform to other rare diseases, and in so doing, to become one of the most
important global leaders in precision genetic medicine to reduce human suffering and treat disease.”
About EXONDYS 51
EXONDYS 51 uses Sarepta’s proprietary phosphorodiamidate morpholino oligomer (PMO) chemistry and exon-skipping
technology to skip exon 51 of the dystrophin gene. EXONDYS 51 is designed to bind to exon 51 of dystrophin pre-mRNA, resulting in
exclusion of this exon during mRNA processing in patients with genetic mutations that are amenable to exon 51 skipping. Exon
skipping is intended to allow for production of an internally truncated dystrophin protein. Data from clinical studies of EXONDYS
51 in a small number of DMD patients have demonstrated a consistent safety and tolerability profile. The pivotal trials were not
designed to evaluate long-term safety and a clinical benefit of EXONDYS 51 has not been established.
Important Safety Information About EXONDYS 51
Adverse reactions in DMD patients (N=8) treated with EXONDYS 51 30 or 50 mg/kg/week by intravenous (IV) infusion
with an incidence of at least 25% more than placebo (N=4) (Study 1, 24 weeks) were (EXONDYS 51, placebo): balance disorder (38%,
0%), vomiting (38%, 0%) and contact dermatitis (25%, 0%). The most common adverse reactions were balance disorder and vomiting.
Because of the small numbers of patients, these represent crude frequencies that may not reflect the frequencies observed in
practice. The 50 mg/kg once weekly dosing regimen of EXONDYS 51 is not recommended.
In the 88 patients who received ≥30 mg/kg/week of EXONDYS 51 for up to 208 weeks in clinical studies, the
following events were reported in ≥10% of patients and occurred more frequently than on the same dose in Study 1: vomiting,
contusion, excoriation, arthralgia, rash, catheter site pain, and upper respiratory tract infection.
There have been reports of transient erythema, facial flushing, and elevated temperature occurring on the day of
EXONDYS 51 infusion.
For further information, please see the full Prescribing Information.
About Sarepta Therapeutics
Sarepta Therapeutics is a commercial-stage biopharmaceutical company focused on the discovery and development of
precision genetic medicine to treat rare neuromuscular diseases. The Company is primarily focused on rapidly advancing the
development of its potentially disease-modifying Duchenne muscular dystrophy (DMD) drug candidates. For more information, please
visit www.sarepta.com.
Forward-Looking Statements
This press release contains forward-looking statements. Any statements contained in this press release that
are not statements of historical fact may be deemed to be forward-looking statements. Words such as "believes," "anticipates,"
"plans," "expects," "will," "intends," "potential," "possible" and similar expressions are intended to identify forward-looking
statements. These forward-looking statements include statements regarding Sarepta’s revenue from EXONDYS 51 in the fourth quarter
of 2017 and in the year 2017; Sarepta’s full-year 2018 EXONDYS 51 revenue guidance and approximately 100 percent year-over-year
growth; Sarepta’s full year 2017 revenue representing one of the most successful rare disease launches in history, and speaking to
the value of EXONDYS 51 and also to the ability of Sarepta’s talented employees to execute on Sarepta’s plans and deliver on its
commitments; Sarepta accelerating its plans in 2018, moving 16 programs through development, and planning for multiple milestones
and inflection points; and Sarepta’s lofty but achievable aspiration to improve and extend the lives of the thousands of children
suffering from DMD, expand its platform to other rare diseases and become one of the most important global leaders in precision
genetic medicine to reduce human suffering and treat disease.
These forward-looking statements involve risks and uncertainties, many of which are beyond Sarepta’s
control. Known risk factors include, among others: the audit of Sarepta’s financial statements for the year ended December 31, 2017
is ongoing and could result in changes to the information; Sarepta may not be able to meet expectations with respect to EXONDYS 51
sales or attain the net revenues it anticipates for 2018, profitability or positive cash‐flow from operations; Sarepta may not be
able to comply with all FDA post‐approval commitments/requirements with respect to EXONDYS 51 in a timely manner or at all; Sarepta
may not be able to obtain regulatory approval for eteplirsen in jurisdictions outside of the U.S., including from the EMA; the
results of Sarepta’s ongoing research and development efforts, including those with strategic partners, and clinical trials for
Sarepta’s product candidates may not be positive or consistent with prior results or demonstrate a safe treatment benefit which
could negatively impact its business; Sarepta may not be able to execute on its business plans and goals, including meeting its
expected or planned regulatory milestones and timelines, clinical development plans, and bringing its product candidates to market,
for various reasons including possible limitations of Sarepta’s financial and other resources, manufacturing limitations that may
not be anticipated or resolved for in a timely manner, results of research and development efforts and/or clinical trials may not
be positive, and regulatory, court or agency decisions, such as decisions by the United States Patent and Trademark Office; and
those risks identified under the heading “Risk Factors” in Sarepta’s most recent Annual Report on Form 10-K for the year ended
December 31, 2016 and most recent Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (SEC) as well as
other SEC filings made by the Company which you are encouraged to review.
Any of the foregoing risks could materially and adversely affect the Company’s business, results of
operations and the trading price of Sarepta’s common stock. For a detailed description of risks and uncertainties Sarepta faces,
you are encouraged to review Sarepta's 2016 Annual Report on Form 10-K and most recent Quarterly Report on Form 10-Q for the
quarter ended September 30, 2017 filed with the Securities and Exchange Commission (SEC) as well as other SEC filings made by
Sarepta. Sarepta cautions investors not to place considerable reliance on the forward-looking statements contained in this press
release. Sarepta does not undertake any obligation to publicly update its forward-looking statements based on events or
circumstances after the date hereof.
Internet Posting of Information
We routinely post information that may be important to investors in the 'For Investors' section of our
website at www.sarepta.com. We encourage investors and potential investors to consult our
website regularly for important information about us.
Source: Sarepta Therapeutics, Inc.
Media and Investors:
Sarepta Therapeutics, Inc.
Ian Estepan, 617-274-4052
iestepan@sarepta.com
or
W2O Group
Brian Reid, 212-257-6725
breid@w2ogroup.com
