JERSEY CITY, N.J., June 11, 2018 /PRNewswire/ -- SCYNEXIS,
Inc. (NASDAQ:SCYX), a biotechnology company developing innovative therapies for difficult-to-treat and often life-threatening
infections, today announced the presentation of data at American Society for Microbiology (ASM) Microbe 2018, June 7-11, 2018, in Atlanta. SCY-078, the first representative of a novel oral
and intravenous (IV) triterpenoid antifungal family, is in clinical development for the treatment of multiple serious fungal
infections, including vulvovaginal candidiasis, invasive candidiasis, invasive aspergillosis and refractory invasive fungal
infections.
"The data presented at ASM Microbe showcase the potent in vitro activity of SCY-078 across a range of Candida
strains, including echinocandin-resistant strains, as well the in vitro synergistic activity of SCY-078 with isavuconazole
against numerous Aspergillus spp., providing further support to our ongoing and planned clinical programs, specifically
FURI, CARES and Aspergillus combination studies," said David Angulo, M.D., Chief Medical
Officer of SCYNEXIS. "The synergistic activity of SCY-078 against Aspergillus spp. has the potential to improve outcomes
in this difficult-to-treat infection, and the distinct changes that SCY-078 induced in the cellular morphology of Candida
strains, when compared to echinocandins, illustrate the differentiated effect of this novel triterpenoid antifungal compound, a
critical feature when addressing the growing concern of multidrug-resistant fungal infections."
Poster Title: Morphological Effect of SCY-078 and Caspofungin on Different Echinocandin-Resistant Candida
Species
The poster describes the results from a study designed to evaluate in vitro, morphological changes when Candida
albicans, C. auris or C. glabrata are exposed to SCY-078, as compared to caspofungin and untreated control. The
morphological findings in this study show the activity of SCY-078 against these Candida species, and clearly show the
activity of SCY-078 is distinguished from the echinocandins based on the results against echinocandin-resistant isolates.
Poster Title: In Vitro Activity of SCY-078 in Combination with Isavuconazole or Amphotericin B against Medically
Important Moulds
The poster describes the results from a study designed to evaluate the in vitro activity of SCY-078 with isavuconazole
or amphotericin B against Aspergillus spp., Scedosporium apiospermum and Mucorales. The findings in this study show
the synergistic activity of SCY-078 and isavuconazole against all evaluated Aspergillus spp., with the greatest
synergistic activity demonstrated against A. fumigatus. These results indicate that the combination of SCY-078 and
mold-active azoles has the potential to serve as an efficacious treatment for invasive aspergillosis and support additional
investigation.
Poster Title: Does Sabouraud Dextrose Broth, Compared to RPMI, Differentiate Susceptibility between Resistant and
Susceptible Candida glabrata and C. albicans Isolates to SCY-078, a Novel β-D-Glucan Synthase Inhibitor, and
Caspofungin?
The poster describes the results from a study designed to evaluate the ability of Sabouraud dextrose broth to identify the
susceptibility of C. glabrata and C. albicans to SCY-078, caspofungin and micafungin. These results show that
minimum inhibitory concentrations (MIC) for SCY-078 and caspofungin were lower in Sabouraud dextrose broth than in RPMI, a
standard medium employed for this determination. This data shows that Sabouraud dextrose broth may be more effective for
determining the susceptibility of strains to SCY-078 and caspofungin.
All presentations are available on the Scientific
Publications page of the SCYNEXIS website.
About SCY-078
SCY-078 is an investigational antifungal agent that is a semi-synthetic derivative of
the natural product enfumafungin. SCY-078 is the first representative of a novel class of structurally-distinct glucan synthase
inhibitors, triterpenoids. This agent combines the well-established activity of glucan synthase inhibitors with the potential
flexibility of having IV and oral formulations. SCY-078 is currently in development for the treatment of fungal infections caused
primarily by Candida (including C. auris) and Aspergillus species. It has
demonstrated broad spectrum antifungal activity, in vitro and in vivo, against multidrug-resistant
pathogens, including azole- and echinocandin-resistant strains. The FDA has granted QIPD and Fast Track designations
for the formulations of SCY-078 for the indications of invasive candidiasis (IC) (including candidemia), invasive
aspergillosis (IA), and VVC, and has granted Orphan Drug Designation for the IC and IA indications.
About SCYNEXIS
SCYNEXIS, Inc. (NASDAQ: SCYX) is a biotechnology company committed to positively impacting the lives of patients
suffering from difficult-to-treat and often life-threatening infections by developing innovative therapies. The SCYNEXIS team has extensive experience in
the life sciences industry, discovering and developing more than 30 innovative medicines over a broad range of therapeutic areas.
The Company's lead product candidate, SCY-078, is a novel IV/oral antifungal agent in Phase 2 clinical and preclinical development for the treatment of
multiple serious and life-threatening invasive fungal infections caused
by Candida and Aspergillus species. For more information, visit www.scynexis.com.
C ONTACT:
I n ve s t o r Relations
Susan Kim
Argot Partners
Tel: 212-600-1902
susan@argotpartners.com
Med i a Relations
George E. MacDougall
MacDougall Biomedical Communications
Tel: 781-235-3093
george@macbiocom.com
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SOURCE SCYNEXIS, Inc.