TSX: PMN; OTCQB: ARFXF
Encouraging results of recent clinical trials in Alzheimer's disease indicate importance of selectively
targeting toxic amyloid-beta oligomers
TORONTO and CAMBRIDGE, MA, Aug. 7,
2018 /CNW/ - ProMIS Neurosciences, Inc. (TSX: PMN; OTCQB: ARFXF), a biotechnology company focused on the discovery and
development of antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases, today
announced it has issued a narrated commentary on key lessons from this year's Alzheimer's Association International Conference
(AAIC).
Results of prior and current clinical trials with therapeutics targeting amyloid-beta (Aß), including encouraging
Phase 2 results of Esai/Biogen's Ban2401 presented at AAIC, indicate that selective targeting of toxic amyloid-beta oligomers
(AßO) is critical for therapeutic efficacy. The importance of neutralizing AßO toxicity represented a
common theme across multiple oral presentations and posters at this year's AAIC.
"A growing body of evidence indicates that AßO, consisting of small aggregates of two, four or twelve
Aß peptides are the toxic oligomers killing neurons in Alzheimer's disease. Numerous scientific studies have shown
that other forms of amyloid-beta, plaque, single Aß monomers, and large Aß aggregates are not toxic to
neurons.", stated Dr. Elliot Goldstein, ProMIS President and CEO
.
"Our humanized PMN310 antibody shows unrivaled selectivity for toxic AßO derived from human AD brains,
with no off-target binding to Aß monomers or plaque. We believe the oligomer selectivity of PMN310 supports a
potential best in class product profile compared to other therapeutic antibodies currently showing promising results in clinical
trials."
ProMIS' clinical candidate, humanized PMN310, is on track to enter Phase 1 clinical testing in the second half of 2019 and
will include biomarker assessment as an integral part of the study design.
ProMIS narrated commentary can be found on the ProMIS Neurosciences website by clicking on the link below:
https://bit.ly/2OgyYlH
About ProMIS Neurosciences, Inc.
ProMIS Neurosciences is a development stage biotechnology company focused on discovering and developing antibody therapeutics
targeting toxic oligomers implicated in the development and progression of neurodegenerative diseases, in particular Alzheimer's
disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). The Company's proprietary target discovery engine
is based on the use of two complementary techniques. The Company applies its thermodynamic, computational discovery
platform—ProMIS™ and Collective Coordinates — to predict novel targets known as Disease Specific Epitopes (DSEs) on the molecular
surface of misfolded proteins. Using this unique precision medicine approach, the Company is developing novel antibody
therapeutics for AD, ALS and PD. ProMIS is headquartered in Toronto, Ontario, with offices
in Cambridge, Massachusetts. ProMIS is listed on the Toronto Stock Exchange under the symbol
PMN, and on the OTCQB Venture Market under the symbol ARFXF.
For further information please consult the Company's website at: www.promisneurosciences.com
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SOURCE ProMIS Neurosciences Inc.
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