Revance Announces Ground-Breaking Data Presentations at Leading International Neurotoxin Conference
- Revance’s long-acting neuromodulator RT002, along with its unique proprietary peptide and formulation
technology, will be featured in 11 podium and poster presentations at the TOXINS 2019 conference in Denmark -
Revance Therapeutics, Inc. (NASDAQ:RVNC), a biotechnology company developing next-generation neuromodulators for use in treating
aesthetic and therapeutic conditions, today announced 11 clinical and non-clinical presentations for DaxibotulinumtoxinA for
Injection (RT002) and the company’s unique proprietary peptide and formulation technology at TOXINS 2019, a leading international
conference on neurotoxins to be held Jan. 16 through 19 in Copenhagen, Denmark.
"We will have a significant presence at the bi-annual TOXINS 2019, which attracts scientific and clinical experts from around
the world who are specifically focused on the basic science and clinical applications of neurotoxins," said Dan Browne, president
and chief executive officer at Revance. “Our 11 presentations will cover a variety of evidence-based clinical results for our lead
product candidate RT002 in treating both glabellar (frown) lines and cervical dystonia, along with detailed examinations of our
unique proprietary peptide and formulation technology. We’re excited to share data on the first new neuromodulator in more than 30
years that delivers high response rates and long-lasting results without compromising safety.”
Revance’s scheduled presentations are:
Podium Presentations
- Pooled Results from Two Phase 3 Pivotal Studies of DaxibotulinumtoxinA for the Treatment of
Glabellar Lines (Jan. 17, 4:30 pm CET, Clinical Workshop 1B). Presenter: Dr. Steven G. Yoelin, Ophthalmologist at Steve
Yoelin MD Medical Associates.
- Outcomes of Week-24 Completers and Subjects who had Follow-Up Beyond Week 24 after a Single
Treatment of DaxibotulinumtoxinA; Results of a Phase 2 Open-Label Dose-Escalating Study in Isolated Cervical Dystonia (Jan.
18, 3:30 pm CET, Clinical Workshop 3A). Presenter: Dr. Atul Patel, Kansas City Bone & Joint Clinic.
Poster Presentations (Jan. 17 and 18, noon to 2:30 pm CET)
Aesthetics
- Pooled Results from Two Phase 3 Pivotal Studies of DaxibotulinumtoxinA for the Treatment of
Glabellar Lines
- Results of a Large Open-Label Safety Study of DaxibotulinumtoxinA in Glabellar Lines
- A Head-to-Head Dose-Ranging Study of DaxibotulinumtoxinA in the Treatment of Glabellar Lines:
Results of the BELMONT Study
Therapeutics
- Immunogenicity of DaxibotulinumtoxinA in Adults with Cervical Dystonia from a Phase 2
Dose-Escalation Multicenter Study
- Outcomes of Week-24 Completers and Subjects who had Follow-Up Beyond Week 24 after a Single
Treatment of DaxibotulinumtoxinA: Results of a Phase 2 Open-Label, Dose-Escalating Study in Isolated Cervical Dystonia
- Methodology of a Phase 2 Randomized, Double-Blind, Placebo-Controlled, Parallel group,
Dose-Ranging 36-week Multicenter Trial to Evaluate the Efficacy and Safety of DaxibotulinumtoxinA for the Treatment of Upper Limb
Spasticity in Adults after Stroke or Traumatic Brain Injury
Non-Clinical
- Revance's Novel Peptide Excipient (RTP004) and its Role in Stabilizing DaxibotulinumtoxinA against
Aggregation
- Development of Cell-Based Potency Assay for Release and Stability Testing of Drug Substance and
Drug Product
- Non-Clinical Overview of DaxibotulinumtoxinA to Support Registration for Human Use
- Novel Peptide Excipient RTP004 Enhances the Binding of Botulinum Neurotoxin, a Cell Binding Domain
HC to Rat Brain Synaptosomes
- Stabilizing Effect of RTP004 on Non-Specific Surface Adsorption in Drug Product Manufacturing of
DaxibotulinumtoxinA
About Revance Therapeutics, Inc.
Revance Therapeutics is an emerging Silicon Valley biotechnology leader developing neuromodulators for the treatment of
aesthetic and therapeutic conditions. Revance uses a unique proprietary peptide excipient technology to create novel,
differentiated therapies. The company’s lead compound, DaxibotulinumtoxinA for Injection (RT002), is in clinical development for a
broad range of aesthetic and therapeutic indications, including glabellar lines, cervical dystonia, plantar fasciitis, upper limb
spasticity and chronic migraine. RT002 has the potential to be the first long-acting neuromodulator. The company is advancing a
robust pipeline of injectable and topical formulations of daxibotulinumtoxinA. More information on Revance may be found at
www.revance.com.
“Revance Therapeutics” and the Revance logo are registered trademarks of Revance Therapeutics, Inc.
Forward-Looking Statements
This press release contains forward-looking statements, including statements related to Revance Therapeutics' 2018 financial
outlook, expected cash burn and other financial performance, the process and timing of, and ability to complete, current and
anticipated future clinical development of our investigational drug product candidates, the initiation, design, timing and results
of our clinical studies, including the SAKURA 3 study of RT002, ASPEN Phase 3 program, JUNIPER Phase 2 and other clinical programs
relating to RT002 and related results and reporting of such results; results of our non-clinical programs; statements about our
business strategy, timeline and other goals and market for our anticipated products, plans and prospects; including our
pre-commercialization plans and timing of our potential BLA filing for RT002 to treat glabellar (frown) lines; and
statements about our ability to obtain regulatory approval with respect to our drug; and potential benefits of our drug product
candidates and our excipient peptide and other technologies.
Forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially from
our expectations. These risks and uncertainties include, but are not limited to: the outcome, cost, and timing of our product
development activities and clinical trials; the uncertain clinical development process, including the risk that clinical trials may
not have an effective design or generate positive results; our ability to obtain and maintain regulatory approval of our drug
product candidates; our ability to obtain funding for our operations; our plans to research, develop, and commercialize our drug
product candidates; our ability to achieve market acceptance of our drug product candidates; unanticipated costs or delays in
research, development, and commercialization efforts; the applicability of clinical study results to actual outcomes; the size and
growth potential of the markets for our drug product candidates; our ability to successfully commercialize our drug product
candidates and the timing of commercialization activities; the rate and degree of market acceptance of our drug product candidates;
our ability to develop sales and marketing capabilities; the accuracy of our estimates regarding expenses, future revenues, capital
requirements and needs for financing; our ability to continue obtaining and maintaining intellectual property protection for our
drug product candidates; and other risks. Detailed information regarding factors that may cause actual results to differ materially
from the results expressed or implied by statements in this press release may be found in Revance's periodic filings with
the Securities and Exchange Commission (the "SEC"), including factors described in the section entitled "Risk Factors" of
our quarterly report on Form 10-Q filed November 2, 2018. These forward-looking statements speak only as of the date hereof.
Revance disclaims any obligation to update these forward-looking statements.
INVESTORS
Revance Therapeutics, Inc.:
Jeanie Herbert
(714) 325-3584
jherbert@revance.com
or
Burns McClellan, Inc.:
John Grimaldi
(212) 213-0006
jgrimaldi@burnsmc.com
or
MEDIA
General Media:
TOGORUN:
Mariann Caprino
(917) 242-1087
m.caprino@togorun.com
or
Trade Media:
Nadine Tosk
(504) 453-8344
nadinepr@gmail.com
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