SYDNEY, March 25, 2019 /PRNewswire/ -- Australian
oncology-focused biotech company Kazia Therapeutics Ltd (ASX: KZA, NASDAQ: KZIA) has been selected to present data from the Phase
I study of Cantrixil in ovarian cancer at the American Association for Cancer Research (AACR) 2019 Annual Meeting.
AACR's Annual Meeting is one of the top-tier academic conferences worldwide and brings together around 20,000 representatives
from academia, industry, government and advocacy organisations from across the globe. The meeting is being held from 29
March to 3 April at the Georgia World Congress Center in Atlanta, Georgia, USA.
Clinical Program Director, Daniel Berg will be presenting on Kazia's Cantrixil Phase I in
ovarian cancer at the event on 1 April 2019. Mr Berg will present data from Part A of the
study -- the dose escalation component -- which completed recruitment in October
2018.
TRX-E-002-1 (Cantrixil), is a third-generation benzopyran molecule with activity against cancer stem cells and is being
developed to treat ovarian cancer. It was developed in Australia and initial preclinical studies
were conducted at Yale University. Cantrixil was granted orphan designation for ovarian cancer by the
US FDA in April 2015.
The abstract presentation is entitled: Phase I Study of Intraperitoneal TRX-E-002-1 in Patients with Persistent or
Recurrent Ovarian Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer: Results of Dose-Escalation Phase.
The abstract has been authored by the trial's Principal Investigators (PIs) - led by the two primary PIs in Australia and the US: Associate Professor Jermaine Coward at the ICON Cancer
Care in Brisbane, Queensland and Dr Don
Dizon at the Lifespan Cancer Institute at Rhode Island Hospital. The trial is being conducted across six sites in the US
and Australia as follows:
|
Country
|
State
|
Site
|
Principal Investigator
|
|
US
|
Rhode Island
|
Lifespan Cancer Institute, Providence
|
Dr. Don Dizon
|
|
US
|
Oklahoma
|
Stephenson Cancer Center, Oklahoma City
|
Assoc. Prof. Kathleen Moore
|
|
US
|
Texas
|
Mary Crowley Cancer Research Centre, Dallas
|
Dr. Minal Barve
|
|
Australia
|
Queensland
|
ICON Cancer Care, Brisbane
|
Assoc. Prof. Jermaine Coward
|
|
Australia
|
New South Wales
|
Westmead Hospital, Sydney
|
Prof. Paul Harnett
|
|
Australia
|
South Australia
|
Flinders Medical Centre, Adelaide
|
Dr. Ganessan Kichenadasse
|
"The key objective with Part A of the Phase I study was to assess the safety of the drug and find the right dose level to take
the study to the next stage. We are delighted to be presenting our data at the AACR meeting and we look forward to discussing our
findings with clinicians and potential partners," said Cantrixil Program Director Daniel Berg.
The presentation session details are as follows:
Session Title: Phase I Clinical Trials: Part 3
Date and Time: Monday April 1, 2019 1:00 PM - 5:00 PM
Location: Georgia World Congress Center, Exhibit Hall B, Poster Section 16
Poster Board Number: 15
Permanent Abstract Number: CT091
Interested parties are encouraged to attend and can add the session to their itinerary here: https://www.abstractsonline.com/pp8/#!/6812/session/1315
Meanwhile, the link to the abstract is here: https://www.abstractsonline.com/pp8/#!/6812/presentation/9899
The content of the abstract and presentation is embargoed until the start of the conference when it will be available through
the above link and on the Kazia website.
***ENDS***
For more information on Kazia Therapeutics or Cantrixil, please visit: www.kaziatherapeutics.com
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SOURCE Kazia Therapeutics Ltd