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Biopharma's LDL Cholesterol-Lowering Drug Emerges as 'Lead Stallion in Safety'

Streetwise Reports, Streetwise Reports
0 Comments| May 30, 2019

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The interim study results for an in-progress trial evaluating this asset are discussed in a ROTH Capital Partners report.

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In a May 20 research report, ROTH Capital Partners analyst Yasmeen Rahimi reported that The Medicines Company's (MDCO:NASDAQ) recent presentation on inclisiran at the National Lipid Association meeting "put the bears to sleep."

At the event, the biopharma reported interim results from ORION-3, a single-dose, open-label, parallel-group study evaluating the pharmacokinetics and pharmacodynamics (PK/PD) and the safety of inclisiran in patients with hepatic impairment compared to patients with normal hepatic function.

The data showed "consistent and durable LDL cholesterol lowering (51%) and spot clean safety, better than the safest cardiovascular disease drug (statins) after three treatment years (five to seven injections) in 290 patients," Rahimi noted.

The analyst highlighted that inclisiran's safety profile, consistent over time in a large patient group, should remove the overhang of siRNA drugs and cause The Medicines Company's stock to rise at least 20%.

Rahimi pointed out, too, that inclisiran is the only drug historically to lower LDL cholesterol from day 210 and have the effect persist through year three, with a time averaged reduction of about 60 milligram per deciliter (60 mg/dl) over 22 months. "A quick calculation of LDL-C lowering (about 60mg/dl) at three years translates to 35% major adverse cardiac events (MACE), setting a new record in the cardiovascular space," she added.

The Medicines Company also revealed a proprietary PK/PD model, which predicts 54% LDL cholesterol reduction in ORION-9, ORION-10 and ORION-11. This would translate into a 30–41% MACE reduction. "This smart move on data transparency not only tempers the bears but [also] ultimately increases the mergers and acquisitions price tag," Rahimi commented.

ROTH has a Buy rating and a $75 per share target price on The Medicines Company, whose current share price is around $34.88.

1) Doresa Banning compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. She or members of her household own securities of the following companies mentioned in the article: None. She or members of her household are paid by the following companies mentioned in this article: None.
2) The following companies mentioned in this article are billboard sponsors of Streetwise Reports: None. Click here for important disclosures about sponsor fees.
3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article until three business days after the publication of the interview or article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases.

Disclosures from ROTH Capital Partners, The Medicines Company, Company Note, May 20, 2019

Regulation Analyst Certification ("Reg AC"): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and its or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed in this report.

ROTH makes a market in shares of The Medicines Company and as such, buys and sells from customers on a principal basis

ROTH Capital Partners, LLC expects to receive or intends to seek compensation for investment banking or other business relationships with the covered companies mentioned in this report in the next three months.

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