Join today and have your say! It’s FREE!

Become a member today, It's free!

We will not release or resell your information to third parties without your permission.
Please Try Again
{{ error }}
By providing my email, I consent to receiving investment related electronic messages from Stockhouse.

or

Sign In

Please Try Again
{{ error }}
Password Hint : {{passwordHint}}
Forgot Password?

or

Please Try Again {{ error }}

Send my password

SUCCESS
An email was sent with password retrieval instructions. Please go to the link in the email message to retrieve your password.

Become a member today, It's free!

We will not release or resell your information to third parties without your permission.

Interim Data Indicate Multiantigen Cell Therapy in Solid Tumors 'Just Might Work'

Streetwise Reports, Streetwise Reports
0 Comments| July 24, 2019

{{labelSign}}  Favorites
{{errorMessage}}

The immuno-oncology company's findings are reviewed in a ROTH Capital Partners report.

Click to enlarge


In a July 22 research note, ROTH Capital Partners analyst Tony Butler reported that "encouraging data" from Marker Therapeutics Inc.'s (MRKR:NASDAQ) Phase I trial, TACTOPS, "could provide an upside to our current price target."

The immuno-oncology company presented these findings surrounding the clinical evaluation of MultiTAA T-cells in pancreatic cancer on July 20 and hosted a follow-up conference call on July 22 to review them.

The promising early outcome is the "chemo-combo cohort (arm A) seemingly outperformed, although it remains too early to call as several patients have been treated for less than 11 months," Butler highlighted.

The analyst reviewed the patient makeup and reported results of all three trial arms.

Arm A was compossed of patients who responded to first-line treatment after diagnosis. In Marker's trial, they were given chemotherapy, either Folfirinox or a combination of gemcitabine and nab-paclitaxel, alternating with MultiTAA T-cells.

Results were that of the nine patients, five (56%) experienced clinical benefit, and two (33%) achieved an overall response as best tumor response. One patient who received Folfirinox had an ongoing complete response at month 11. Two patients receiving administered the gemcitabine combination had ongoing partial responses at months six and 11. "Considering that median overall survival for patients receiving Folfirinox and gemcitabine plus nab-paclitaxel are 11.5 months and 8.5 months, respectively, these ongoing responses are encouraging," Butler indicated.

Arm B were patients who could not tolerate or were refractory to first-line chemotherapy. They were given MultiTAA T-cells as a monotherapy. One of six (17%) patients with metastasized disease achieved stable disease that lasted for up to seven months.

Arm C enrolled patients with resectable disease who got one preoperative infusion and will receive five additional doses following surgery as adjuvant therapy. Two of three patients (67%) achieved stable disease that lasted for an average of 5.5 months.

About the Phase 1 study results, Butler concluded, "Overall, we find the early evidence of efficacy of tumor shrinkage measured using independent assessments encouraging." He relayed that Marker's management team noted the possibility of conducting a subsequent study similar to arm A in which patients are administered MultiTAA concurrently with chemotherapy.

ROTH has a Buy rating and a $10 per share target price on Marker Therapeutics, whose stock is trading at around $5.50 per share.

Disclosure:
1) Doresa Banning compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. She or members of her household own securities of the following companies mentioned in the article: None. She or members of her household are paid by the following companies mentioned in this article: None.
2) The following companies mentioned in this article are billboard sponsors of Streetwise Reports: None. Click here for important disclosures about sponsor fees.
3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article until three business days after the publication of the interview or article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases.

Disclosures from ROTH Capital Partners, Market Therapeutics, Inc., Flash Note, July 22, 2019

Regulation Analyst Certification ("Reg AC"): The research analyst primarily responsible for the content of this report certifies the following under Reg AC: I hereby certify that all views expressed in this report accurately reflect my personal views about the subject company or companies and its or their securities. I also certify that no part of my compensation was, is or will be, directly or indirectly, related to the specific recommendations or views expressed in this report.

ROTH makes a market in shares of Marker Therapeutics, Inc. and as such, buys and sells from customers on a principal basis.

ROTH Capital Partners, LLC expects to receive or intends to seek compensation for investment banking or other business relationships with the covered companies mentioned in this report in the next three months.



{{labelSign}}  Favorites
{{errorMessage}}

Get the latest news and updates from Stockhouse on social media

Follow STOCKHOUSE Today

Featured Company