Acasti Pharma Inc ACST

Loss of efficacy in 4gram colt group?

[Pumpkin49]

Hey folks. What are your thoughts on there being a loss of efficacy in triglyceride reduction for the 4g group from 4 weeks to 8 weeks. At 4 weeks the reduction was 18.8% and at 8 weeks it was at 14.4%. I know the percentage reduction will be higher in trilogy compared to colt because we're starting with a patient group that has severe high triglycerides vs colt which was mostly mild to moderate. Still, I'm wondering about that loss of efficacy as colt progressed from 4 to 8 weeks.

colt study here (see page 7 for conclusions) : https://d1io3yog0oux5.cloudfront.net/acastipharma/files/pages/acastipharma/db/700/description/presentation-20140501.pdf

also this other study seems to back up a loss of efficacy as the weeks progress at the 4g group. 

https://www.sciencedirect.com/science/article/pii/S0271531713002832

thoughts?  This is the only thing I have found to be concerned about in my dd. Help appreciated

[Francine01]

P. 4 n =62 at 4gr 8 weeks , its -21.6 % and far more important I see cholesterol -8.4%. This secondary end point will us rich!  GLTA

[Pumpkin49]

Thank you, Francine and everyone for responding. Francine, I took a closer look and see that the mean percentage change for TG from baseline at 4 weeks being 15.4% and at 8 weeks being -21.6%.  Considering that these patients had TG levels between 200 and 877, Trilogy should knock it out of the park with all patients above 500 -- and up to 1500.