RE:RE:RE:RE:RE:RE:AstraZeneca's ADC disappoints - on severe adverse eventsAs posted earlier in this thread Pfizer has 12 ADCs in its pipeline that fall into one of four categories: vedotin ADCs; ADCs employing TOPO1 inhibitor payloads; next-gen auristatin ADCs with potentially improved tolerability; and ADCs with novel payload mechanisms of action.
Earleir research work conducted in 2019 has demonstrated that combination of a oncolytic reovirus and topoisomerase (TOPO1) inhibitors (i.e. irinotecan) may provide a potent therapeutic option for patients afflicted with triple-negative breast cancer., further suggesting that ONCY's pelareorep can be used in combination with ADCs for the treatment of breast cancer, for example. This builds "The Dude's" post on stocktwits which followed that irinotecan (Onivdye ) is the standard of care (SOC) in the treatment of Pancreatic Cancer with cross-over to breast cancer and has recently been approved with a new nanoparticle formulation.
Folfirinox is a combination of chemotherapy drugs that includes leucovorin calcium (folinic acid), fluorourail, irinotecan hydrochloride, and oxaliplatin.
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00540
https://stocktwits.com/Dude1234/message/564107776