RE:RE:RE:RE:CD8+ TiLs and T-cell exhaustionAccording to rearchers like James J. Mul, PhD, immunologist and associate center director of translational science at Moffitt Cancer Center, an I/O strategy under investigation involves inducing TILs in tumors that do not produce them through the use of oncolytic viruses, which turn cold tumors into hot tumors to generate TILs, by stimulating the innate and adaptive immune system while remodeling the tumor microenvironment (TME) for the sequential addition of immune checkpoint inhibitors, as ONCY is demonstrating, and which has been discussed in multiple posts on this message board.