RE:RE:RE:RE:RE:CD8+ TiLs and T-cell exhaustionApril 02, 2024 - New paper appearing in JAMA concludes that: "In patients with early-stage TNBC who did not undergo adjuvant or neoadjuvant chemotherapy, breast cancer tissue with a higher abundance of TIL levels was associated with significantly better survival. These results suggest that breast tissue TIL abundance is a prognostic factor for patients with early-stage TNBC."
https://jamanetwork.com/journals/jama/article-abstract/2816923
ONCY AWARE-1 study has demonstrated the expansion of pre-existing TiLs in the blood. In addition sequencing of T cell receptors (TCR) showed a more prominent expansion of TiLs in the blood and the decrease in tumor size leading to the conclusion that pelareorep is an effective immunotherapy.
https://www.newswire.ca/news-releases/oncolytics-biotech-r-and-solti-present-positive-translational-data-at-sabcs-832342590.html