RE:RE:RE:CD8+ TiLs and T-cell exhaustionWhat is of particular matter is pelareorep ability to expand new and existing TiLs in the blood and tumor cell, resulting in enhanced T cell killing of the pelareorep infected cancer cells, resulting from pelareorep's stimulation of the innate and adaptive immune system, and the overcoming of T cell exhaustion, that T cell expanders (I.e.BiTes) are seeking to achieve.
Clonal T cell expansion (which pelareorep is capable of achieving) is the process of T cell activation and proliferation which occurs naturally in vivo when the human body is actively fighting an infection or an immune system attack.
"Accordingly, pela therapy may offer a means to directly expand TILs without the need for tumor resection, ex vivo TIL expansion, T cell ablation and IL-2 therapy."