RE:RE:4050 question?M80,
I'm not a scientist, but for what I understand is that PBI-4050 is acting on several receptors involved in the fibrosis mechanism, which is complex (for me...).
Take a look at slide 33 of the NY presentation from Prometic site. It's very informative.
Esbriet is probably acting on 1 single receptor involve in the fibrosis. So you can slow the mechanism of the fibrosis, but can't stop it as other cells will continue to induce it.
As we had here the coldest month of February since 115 years, I will attempt to compare fibrosis with house insulation.
I would say Esbriet is the door and windows of the house. With good windows, you will reduce the lost of heat.
However, you will still loose heat, if you don't put foam around the windows and doors to block the leak.
PBI-4050 will also be the foam, and silicon around the windows and doors, the fiberglass in the attic, and the thermic panel in the walls.
At the end, there less leak.
So my understanding is that by acting on several receptors at the same time, you reduce at least the fibrosis more effectively. And if it can be stopped and reverse, well it will be even better for the patients!
Mechanism of action of PBI-4050 for dummies (like me)
