RE:Cystic Fibrosis and Vertexplilong, My understanding is that PLI is not aiming to cure CF, but rather treat the related fibrosis that exacerbates the condition, specifically fibrosis in the pancreas which leads to diabetes in CF patients. 4050 is still very much a fiborsis and diabetes drug. They are just looking at another subgroup of patients it may help.
Taking proteins from one person and giving to another is cheap and low risk, genetic therapy is expensive and risky. The wound healing indication is not a genetic problem, and wound healing is now expected to be the biggest contributor to PPPS revenue. It would be great for patients if gene therapy solved some conditions, but I don't see it changing the PLI investment thesis.