RE:Clinically/statistically significant reduction waist size?I'm not a specialist in this matter.
For what I know, when HbA1c is over 6.5%, the first line of treatment is metfornin.
When a patient on metformin still over 6.5% of HbA1c, a second line of treatment is giving.
Those medications in second lines are insulin secretagogues, which cause the pancreas to produce and secrete insulin-and can lead to weight gain as a side effect.
Maybe the term "significant" is used simply because there a loss, not a gain in the waist circumference, and a reduction in the body mass index.
I guess I will need an expert opinion for this one.