The Bloom Burton report (molecular structure of PBI-4050). First, we can take a look at the molecular structure of PBI-4050, as explain in the patent.
While I'm not an expert in chemistry, but what was in the report, is total assumptions, with simply no facts to support their c-r-a-p.
They show a part of a molecule, however, looking below you will see that it's not as simple as they put it in the report. You just can't put only one piece of a puzzle and make full conclusion based on that piece.
From the patent:
More particularly, the present invention concerns a method for preventing and/or slowing progression of and/or treating a fibrotic disease in a subject in need thereof. The fibrotic disease is pulmonary fibrosis, liver fibrosis, skin fibrosis or cardiac fibrosis. The method comprises the administration of a therapeutically effective amount of a compound represented by the formula:
or a pharmaceutically acceptable salt thereof, wherein
A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; or is preferably C5 alkyl, C5 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3; or is preferably C6 alkyl, C6 alkenyl, C(0)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 4;
Ri is H, OH or F; or is preferably H or OH;
R2 is H, OH, F or CH2-OH; or is preferably H, OH or F; or is preferably H or OH;
R3 is H, OH, F or CH2Ph; or is preferably H, OH or F; or is preferably H or OH;
R4 is H, OH or F; or is preferably H or OH;
Q is
1 ) (CH2)mC(0)OH wherein m is 1 or 2,
2) CH(CH3)C(0)OH,
3) C(CH3)2C(0)OH,
4) CH(F)-C(0)OH,
5) CF2-C(0)OH, or
6) C(0)-C(0)OH.