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ProMIS Neurosciences Inc PMN

Healthcare Biotechnology
ProMIS Neurosciences Inc. is a development stage biotechnology company. The Company is focused on generating and developing antibody therapeutics selectively targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA), an alpha-synucleinopathy. Its proprietary target discovery engine applies a thermodynamic, computational discovery platform - ProMIS and Collective Coordinates - to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this approach, the Company is developing novel antibody therapeutics for AD, ALS and MSA. Its product portfolio includes PMN310 / Amyloid-beta, PMN267 / TDP-43, and PMN442 / Alpha-synuclein. The Company plans to investigate additional synucleinopathies, including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Its wholly owned subsidiary is ProMIS Neurosciences (US) Inc.


NDAQ:PMN - Post by User

ProMIS Neurosciences Inc
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Post by Gbathaton Jul 08, 2020 4:43pm
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Post# 31241761

Kupiec quoted in biogen article

Kupiec quoted in biogen articleKupiec quoted in biogen article
https://www.neurologylive.com/clinical-focus/biogen-submits-bla-for-aducanumab-in-alzheimer-disease


James Kupiec, MD, chief medical officer for ProMIS Neurosciences, noted to NeurologyLive that this re-analysis of the larger dataset showed that aducanumab was effective in slowing the progression of Alzheimer at a higher dose, and then data released at the Clinical Trials in Alzheimer’s Disease (CTAD) meeting in San Diego in December 2019 strengthened its potential to become the first disease-modifying therapy (DMT) for Alzheimer. "This stunning reversal not only resurrected hope for a near-term therapy for Alzheimer, it also—perhaps more importantly—reinvigorated innovation supporting next-generation therapies that demonstrate more precise selectivity for amyloid-beta oligomers, not amyloid-beta plaque. At CTAD, Biogen provided additional analyses to support their conclusion: high-dose, long-duration aducanumab exposure can modify the Alzheimer process and provide clinical benefit," Kupiec wrote.
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