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ProMIS Neurosciences Inc PMN

ProMIS Neurosciences Inc. is a development stage biotechnology company. The Company is focused on generating and developing antibody therapeutics selectively targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA), an alpha-synucleinopathy. Its proprietary target discovery engine applies a thermodynamic, computational discovery platform - ProMIS and Collective Coordinates - to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this approach, the Company is developing novel antibody therapeutics for AD, ALS and MSA. Its product portfolio includes PMN310 / Amyloid-beta, PMN267 / TDP-43, and PMN442 / Alpha-synuclein. The Company plans to investigate additional synucleinopathies, including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Its wholly owned subsidiary is ProMIS Neurosciences (US) Inc.


NDAQ:PMN - Post by User

Comment by Gbathaton Sep 06, 2020 7:02pm
173 Views
Post# 31517122

RE:RE:A positive

RE:RE:A positiveFrom the Zack's article, it sounds like the potential funding for PHI testing is contingent on the FDA approval of Biogen's aducanumab, which would essentially validated amyloid beta as a target for AD treatment.

While the aducanumab data shows limited efficacy, it does show significant levels of benefit. 

Personally, I wish the PHI would just launch, but it's not my $10M, so it is easy for me to say that.  It would probably be a tough process if aducanumab were denied approval, basically starting from scratch in validating amyloid beta as a target to the approval authorities.  By leveraging Biogen's effort, I would guess that the PMN310 pathway to market would be more efficient for said potential investor.

These are just my opinions based on public documents.  There may be more happening behind the scenes.
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