RE:RE:Sanofi acquires pre-clinical TME modulator for $1.225 BlnBi-specifics induce T-cell exhaustion
https://www.youtube.com/watch?v=9XkjCi0XQxw&ab_channel=VJHemOnc%E2%80%93VideoJournalofHematologicalOncology
Conversely ONCY's pelareorep is able to overcome T-cell exhaustion by creating novel CD8 T-cells/reactivates by ehaancing T-cell clonality as has been discussed beforehand. Refer to the following Dec.15,2021 paper:
Immune checkpoint blockade augments changes within oncolytic virus-induced cancer MHC-I peptidome, creating novel antitumor CD8 T cell reactivities
https://pubmed.ncbi.nlm.nih.gov/34922008/