RE:ONCY's pelareorep activates interferon (IFN) signallingHypoxia-inducible factor-1α (HIF-1a) is a direct transcriptional suppressor of interferon regulatory factors, the transcriptional activators of type I IFN.
These findings may aid in understanding and control of impaired IFN production by severe acute respiratory syndrome coronavirus 2 infection .... and why Big Pharma companies like Pfizer, Moderna, BMS, Roche, MerckKGaA and others are be interested in ONCY as an acquisition targert - since these Big Pharma coompanies and others, have all been involved in the development of various Covid-19 vaccine therapies and now want to pursue vaccines (oncolytic virus) in the treatment of cancer.
These Big Pharma companies have developed their own "proof-of-concept" studies around vaccines and have become more knowledgeable in the concept of using an oncolytic virus like ONCY's pelareorep, in the treatment of cancer since ONCY's oncolytic virus pelareorep down-regulates HIF-1a which inturn down-regulates adenosine, a downstream chemokine-like catalyst in the TME hypoxia pathway, that acts as a potent TME immunosuppressive agent.
https://www.pnas.org/doi/10.1073/pnas.2106017118