RE:RE:ONCY's pelareorep activates interferon (IFN) signallingIn an earlier post I explained how ONCY's oncolytic virus pelareorep down-regulates HIF-1a by an activated IFN-gamma, which in turn down-regulates adenosine, a downstream chemokine-like catalyst in the TME hypoxia pathway, that acts as a potent TME immunosuppressive agent.
As further background, in 2019 the Nobel Prize in Physiology or Medicine was awarded to William G. Kaelin Jr., Sir Peter J. Ratcliffe, and Gregg L. Semenza for their discovery of hypoxia-inducible factor (HIF), a key transcription factor that regulates gene expression in response to decreases in cellular oxygenation.
ONCY's pelareorep MOA in remodeling an immunosuppressive TME in advance of the sequential addition of a checkpoint inhibitor is supported by Gregg Semenza's work that awarded him the 2019 Nobel Prize in Physiology and Medicine.